TY - JOUR
T1 - Acute and chronic effects of exercise on the kynurenine pathway in humans
T2 - A brief review and future perspectives
AU - Metcalfe, Alan J
AU - Koliamitra, Christina
AU - Javelle, Florian
AU - Bloch, Wilhelm
AU - Zimmer, Philipp
N1 - Copyright © 2018. Published by Elsevier Inc.
PY - 2018/10/1
Y1 - 2018/10/1
N2 - Tryptophan (TRP) is an essential amino acid. Metabolites of TRP have been identified as important mediators in immune regulation and function of the central nervous system. Inflammation strongly stimulates to the breakdown of TRP into Kynurenine (KYN), representing the initial step of the KYN pathway. Recently, exercise interventions have been able to demonstrate a modification of the KYN pathway plausibly by altering inflammation. However, modifications differ between acute and chronic exercise interventions. As such, this review examines the current studies that have investigated the effect of an acute (single bout) or chronic (training) exercise intervention on levels of TRP and KYN in both healthy and diseased populations.
AB - Tryptophan (TRP) is an essential amino acid. Metabolites of TRP have been identified as important mediators in immune regulation and function of the central nervous system. Inflammation strongly stimulates to the breakdown of TRP into Kynurenine (KYN), representing the initial step of the KYN pathway. Recently, exercise interventions have been able to demonstrate a modification of the KYN pathway plausibly by altering inflammation. However, modifications differ between acute and chronic exercise interventions. As such, this review examines the current studies that have investigated the effect of an acute (single bout) or chronic (training) exercise intervention on levels of TRP and KYN in both healthy and diseased populations.
U2 - 10.1016/j.physbeh.2018.07.015
DO - 10.1016/j.physbeh.2018.07.015
M3 - Journal articles
C2 - 30031753
SN - 0031-9384
VL - 194
SP - 583
EP - 587
JO - Physiology & behavior
JF - Physiology & behavior
ER -