Acute responses of cytokines and adipokines to aerobic exercise in relapsing vs. remitting women with multiple sclerosis

Nastaran Majdinasab; Robert W Motl; Motahare Mokhtarzade; Philipp Zimmer; Rouholah Ranjbar; Charly Keytsman; Tom Cullen; Raoof Negaresh; Julien S Baker

doi:10.1016/j.ctcp.2018.03.004

Acute responses of cytokines and adipokines to aerobic exercise in relapsing vs. remitting women with multiple sclerosis

Nastaran Majdinasab, Robert W Motl, Motahare Mokhtarzade, Philipp Zimmer, Rouholah Ranjbar, Charly Keytsman, Tom Cullen, Raoof Negaresh, Julien S Baker

Abteilung Molekulare und zelluläre Sportmedizin

Publikation: Beitrag in Fachzeitschrift › Zeitschriftenaufsätze › Forschung › Begutachtung

Abstract

OBJECTIVE: To examine the acute effect of exercise on cytokines and adipokines during relapse and the remitting phase of multiple sclerosis (MS).

METHODS: Thirty women with MS in the relapsing or remitting phase were matched with fifteen healthy controls. Participants performed a single-bout of aerobic exercise at 60-70% maximal heart rate. Furthermore, five women in the relapsing phase were enrolled (control relapse) and did not receive any intervention. Blood samples were taken before, immediately after, 1-h and 6-h after the exercise.

RESULTS: Levels of IL-10 and TNF-α in response to exercise were similar in healthy and MS remitting subjects. Compared to baseline, TNF-α levels in relapsing subjects were significantly decreased immediately after exercise. Immediately following exercise, leptin levels significantly decreased in relapsing subjects. Adiponectin and IL-6 showed no significant difference between groups.

CONCLUSION: After relapse, exercise does not induce inflammatory cytokine response and temporarily improves both cytokine and adipokine balance.

Originalsprache	Englisch
Zeitschrift	Complementary therapies in clinical practice
Jahrgang	31
Seiten (von - bis)	295-301
Seitenumfang	7
ISSN	1744-3881
DOIs	https://doi.org/10.1016/j.ctcp.2018.03.004
Publikationsstatus	Veröffentlicht - 05.2018

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10.1016/j.ctcp.2018.03.004

Zitation

@article{be154a09f18c498db2c4759b95dc2e7b,

title = "Acute responses of cytokines and adipokines to aerobic exercise in relapsing vs. remitting women with multiple sclerosis",

abstract = "OBJECTIVE: To examine the acute effect of exercise on cytokines and adipokines during relapse and the remitting phase of multiple sclerosis (MS).METHODS: Thirty women with MS in the relapsing or remitting phase were matched with fifteen healthy controls. Participants performed a single-bout of aerobic exercise at 60-70% maximal heart rate. Furthermore, five women in the relapsing phase were enrolled (control relapse) and did not receive any intervention. Blood samples were taken before, immediately after, 1-h and 6-h after the exercise.RESULTS: Levels of IL-10 and TNF-α in response to exercise were similar in healthy and MS remitting subjects. Compared to baseline, TNF-α levels in relapsing subjects were significantly decreased immediately after exercise. Immediately following exercise, leptin levels significantly decreased in relapsing subjects. Adiponectin and IL-6 showed no significant difference between groups.CONCLUSION: After relapse, exercise does not induce inflammatory cytokine response and temporarily improves both cytokine and adipokine balance.",

keywords = "Journal Article",

author = "Nastaran Majdinasab and Motl, {Robert W} and Motahare Mokhtarzade and Philipp Zimmer and Rouholah Ranjbar and Charly Keytsman and Tom Cullen and Raoof Negaresh and Baker, {Julien S}",

year = "2018",

month = may,

doi = "10.1016/j.ctcp.2018.03.004",

language = "English",

volume = "31",

pages = "295--301",

journal = "Complementary therapies in clinical practice",

issn = "1744-3881",

publisher = "Churchill Livingstone",

}

Acute responses of cytokines and adipokines to aerobic exercise in relapsing vs. remitting women with multiple sclerosis. / Majdinasab, Nastaran; Motl, Robert W; Mokhtarzade, Motahare et al.
in: Complementary therapies in clinical practice, Jahrgang 31, 05.2018, S. 295-301.

Publikation: Beitrag in Fachzeitschrift › Zeitschriftenaufsätze › Forschung › Begutachtung

TY - JOUR

T1 - Acute responses of cytokines and adipokines to aerobic exercise in relapsing vs. remitting women with multiple sclerosis

AU - Majdinasab, Nastaran

AU - Motl, Robert W

AU - Mokhtarzade, Motahare

AU - Zimmer, Philipp

AU - Ranjbar, Rouholah

AU - Keytsman, Charly

AU - Cullen, Tom

AU - Negaresh, Raoof

AU - Baker, Julien S

PY - 2018/5

Y1 - 2018/5

N2 - OBJECTIVE: To examine the acute effect of exercise on cytokines and adipokines during relapse and the remitting phase of multiple sclerosis (MS).METHODS: Thirty women with MS in the relapsing or remitting phase were matched with fifteen healthy controls. Participants performed a single-bout of aerobic exercise at 60-70% maximal heart rate. Furthermore, five women in the relapsing phase were enrolled (control relapse) and did not receive any intervention. Blood samples were taken before, immediately after, 1-h and 6-h after the exercise.RESULTS: Levels of IL-10 and TNF-α in response to exercise were similar in healthy and MS remitting subjects. Compared to baseline, TNF-α levels in relapsing subjects were significantly decreased immediately after exercise. Immediately following exercise, leptin levels significantly decreased in relapsing subjects. Adiponectin and IL-6 showed no significant difference between groups.CONCLUSION: After relapse, exercise does not induce inflammatory cytokine response and temporarily improves both cytokine and adipokine balance.

AB - OBJECTIVE: To examine the acute effect of exercise on cytokines and adipokines during relapse and the remitting phase of multiple sclerosis (MS).METHODS: Thirty women with MS in the relapsing or remitting phase were matched with fifteen healthy controls. Participants performed a single-bout of aerobic exercise at 60-70% maximal heart rate. Furthermore, five women in the relapsing phase were enrolled (control relapse) and did not receive any intervention. Blood samples were taken before, immediately after, 1-h and 6-h after the exercise.RESULTS: Levels of IL-10 and TNF-α in response to exercise were similar in healthy and MS remitting subjects. Compared to baseline, TNF-α levels in relapsing subjects were significantly decreased immediately after exercise. Immediately following exercise, leptin levels significantly decreased in relapsing subjects. Adiponectin and IL-6 showed no significant difference between groups.CONCLUSION: After relapse, exercise does not induce inflammatory cytokine response and temporarily improves both cytokine and adipokine balance.

KW - Journal Article

U2 - 10.1016/j.ctcp.2018.03.004

DO - 10.1016/j.ctcp.2018.03.004

M3 - Journal articles

C2 - 29705471

SN - 1744-3881

VL - 31

SP - 295

EP - 301

JO - Complementary therapies in clinical practice

JF - Complementary therapies in clinical practice

ER -

Acute responses of cytokines and adipokines to aerobic exercise in relapsing vs. remitting women with multiple sclerosis

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