Advanced glycation end products in intervertebral discs and hip joint capsules: correlation with senile amyloid?

Tina Foitschik, Wolfgang Saeger, Mona Riebe, Christoph Röcken

Publikation: Beitrag in FachzeitschriftZeitschriftenaufsätzeForschungBegutachtung


Advanced glycation end-products (AGEs) may be involved in either amyloidogenesis or complications related to amyloid. The incidence of AGE increases with age as does the prevalence of amyloid affecting the hip joint capsule and intervertebral discs. We hypothesized that AGEs may be involved in the pathology of these amyloidoses and investigated the spatial and temporal relationship between AGEs and amyloid of intervertebral discs and hip joint capsules. Using immunohistochemistry, AGEs were found in all 71 intervertebral discs and all 87 hip joint capsules. Amyloid was present in 59 (83%) intervertebral discs and 65 (75%) hip joint capsules. AGEs were found in the immediate vicinity of amyloid deposits in 104 of 253 (41%) investigated amyloid deposits of the intervertebral discs and 159 of 311 (51%) investigated amyloid deposits of the hip joint capsules. However, only rarely were AGEs demonstrated within amyloid deposits. No linear correlation was found between the amount of AGEs and the amount of amyloid deposited. As AGEs are more common than amyloid in intervertebral discs and hip joint capsules, it is conceivable to suggest that AGEs might be involved in the pathogenesis of amyloid at these anatomical sites. However, the amyloid proteins appear not to be modified and AGE modification is not a general characteristic of senile amyloidoses.
ZeitschriftAmyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis
Seiten (von - bis)167-173
PublikationsstatusVeröffentlicht - 2005

Fachgebiete und Schlagwörter

  • Adult
  • Aged
  • Aged, 80 and over
  • Aging/metabolism/pathology
  • Alzheimer Disease/metabolism
  • Amyloid/metabolism
  • Amyloidosis/diagnosis/metabolism/pathology
  • Female
  • Glycosylation End Products, Advanced/metabolism
  • Hip Joint/metabolism/pathology
  • Humans
  • Intervertebral Disc/metabolism/pathology
  • Joint Capsule/metabolism/pathology
  • Male
  • Middle Aged