Effects Of Cannabidiol Supplementation On The Skeletal Muscle Regeneration

Cannabidiol (CBD) is a non-psychotropic cannabinoid extracted from cannabis sativa and is mainly sold as a nutrition supplement. The pharmacological effects of CBD are a matter of discussion in research. Anti-inflammatory activities and effects on muscle relaxation of CBD haven been demonstrated in studies. However, there is only limited information on the direct effects of CBD on skeletal muscle regeneration (SMR) after physical activity. The purpose of this study was to investigate effects of CBD on SMR after intensive resistance training (IRT). METHOD: Participants ingested 60mg of CBD or placebo directly after IRT. The study was conducted as a randomized double-blind study in crossover design. Muscle damage as serum creatine kinase (CK) and myoglobin (Myo) as well as performance in 1RM back squat (1RM BS) before and at different times after exercise (+24h, +48h, +72h) are investigated. After the pre-performance tests, 3 sets of BS with 12 repetitions were performed with an intensity of 70%, followed by 3 sets of low jumps with 15 repetitions. Subsequently, the subjects received either a drink with CBD or a placebo drink. No further food was allowed to be consumed in the next 3h. After 24h, 48h and 72h further blood samples were taken and the performance in BS was examined. After two weeks of wash out period, the intervention was repeated. results: CBD administration inhibits significantly the increase of serum CK 24h after exercise (CBD: 244.6U/L SD 65.5 to 332,5U/L SD 97.8, +87.88U/L; PL: 213.8U/L SD 95.0 to 479.9U/L SD 262.6, +265.89U/L) demonstrating a reduction of skeletal muscle damage. However, the 1 RM BS of the CBD group 24h after exercise was significantly lower in comparison to the PL group (CBD: 152.81kg SD 17.90 to 146.26kg SD 16.04, -6.56kg; PL: 150.31kg SD 18.63 to 146.56kg SD 16.85, -3.75kg). In conclusion, the current results show a reduction of skeletal muscle damage 24h after training through CBD supplementation. However, the 1RM BS also deteriorates at the same time which is very likely caused by skeletal muscle relaxation effects of CBD. To investigate whether these findings can be interpreted as beneficial or adverse with respect to skeletal muscle regeneration further investigations are currently ongoing to investigate skeletal muscle performance in a time dependent manner after CBD administration.

(PDF) Effects Of Cannabidiol Supplementation On The Skeletal Muscle Regeneration After Intensive Resistance Training: 2769 Board #230 May 29 9:30 AM - 11:00 AM. Available from: https://www.researchgate.net/publication/342811881_Effects_Of_Cannabidiol_Supplementation_On_The_Skeletal_Muscle_Regeneration_After_Intensive_Resistance_Training_2769_Board_230_May_29_930_AM_-_1100_AM#fullTextFileContent [accessed May 05 2021].