Mass spectrometry of new growth promoting drugs : hydantoin-derived selective androgen receptor modulators and growth hormone secretagogues

Publikation: Beitrag in Buch/Bericht/KonferenzbandKonferenzbeitrag - Aufsatz in KonferenzbandForschung

Abstract

The drugs donepezil as well as rivastigmine are commonly used for the treatment of symptoms arising from Alzheimer's disease by extending the half-life of the neurotransmitter acetylcholine by inhibition of its hydrolysis mediated by acetylcholine esterase. The increased concentration of hypothalamic acetylcholine results in a suppression of somatostatin, a fact which is assumed to cause an improved availability of endogenously produced GH. A screening and confirmation assay for donepezil, rivastigmine, galantamine, as well as some major metabolites and a structural analogue to SM-130686 in human urine was developed based an mass spectrometric studies using LC-ESI-MS/MS. New growth promoting drugs based on either GH secretagogue or SARM activity were studied using synthesized and commercially available reference material and high resolution/high accuracy MSn. Based on characteristic product ions drugs, were measured from urine specimens employing LC-MS/MS instruments that shall allow their detection in doping control samples. Neither bicyclic hydantoins nor orally active GH secretagogues such as compound 1 have received clinical approval yet, but their potential for being misused in sports is very high and test methods might be necessary very soon. Aus dem Text (geändert)
OriginalspracheEnglisch
TitelRecent advances in doping analysis (15) : Proceedings of the Manfred Donike Workshop ; 25th Cologne Workshop on Dope Analysis 25th February to 2nd March 2007
Herausgeber*innenWilhelm Schänzer, Hans Geyer, A. Gotzmann, Ute Mareck
Seitenumfang10
Herausgeber (Verlag)Sportverlag Strauß
Erscheinungsdatum2007
Seiten263-272
PublikationsstatusVeröffentlicht - 2007
VeranstaltungCologne Workshop on Dope Analysis - Köln, Deutschland
Dauer: 25.02.200702.03.2007
Konferenznummer: 25

Fachgebiete und Schlagwörter

  • Biochemie
  • Doping
  • Dopingnachweis
  • Flüssigkeitschromatographie
  • Massenspektrometrie
  • Messverfahren
  • Peptid
  • Sportmedizin
  • Steroid, anaboles
  • Untersuchungsmethode
  • Wachstumshormon

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