TY - JOUR
T1 - SARS-CoV-2 Altered Hemorheological and Hematological Parameters during One-Month Observation Period in Critically Ill COVID-19 Patients
AU - Bizjak, Daniel Alexander
AU - John, Lucas
AU - Matits, Lynn
AU - Uhl, Alisa
AU - Schulz, Sebastian Victor Waldemar
AU - Schellenberg, Jana
AU - Peifer, Johannes
AU - Bloch, Wilhelm
AU - Weiß, Manfred
AU - Grüner, Beate
AU - Bracht, Hendrik
AU - Steinacker, Jürgen Michael
AU - Grau, Marijke
N1 - © 2022 by the authors.
PY - 2022/12/5
Y1 - 2022/12/5
N2 - Hematological and hemorheological parameters are known to be altered in
COVID-19; however, the value of combined monitoring in order to deduce
disease severity is only scarcely examined. A total of 44 acute
SARS-CoV-2-infected patients (aCOV) and 44 age-matched healthy controls
(Con) were included. Blood of aCOV was sampled at admission (T0), and at
day 2 (T2), day 5 (T5), day 10 (T10), and day 30 (T30) while blood of
Con was only sampled once. Inter- and intra-group differences were
calculated for hematological and hemorheological parameters. Except for
mean cellular volume and mean cellular hemoglobin, all blood cell
parameters were significantly different between aCOV and Con. During the
acute disease state (T0–T5), hematological and hemorheological
parameters were highly altered in aCOV; in particular, anemic conditions
and increased immune cell response/inflammation, oxidative/nitrosative
stress, decreased deformability, as well as increased aggregation, were
observed. During treatment and convalescence until T30, almost all
abnormal values of aCOV improved towards Con values. During the acute
state of the COVID-19 disease, the hematological, as well as the
hemorheological system, show fast and potentially pathological changes
that might contribute to the progression of the disease, but changes
appear to be largely reversible after four weeks. Measuring RBC
deformability and aggregation, as well as oxidative stress induction,
may be helpful in monitoring critically ill COVID-19 patients.
AB - Hematological and hemorheological parameters are known to be altered in
COVID-19; however, the value of combined monitoring in order to deduce
disease severity is only scarcely examined. A total of 44 acute
SARS-CoV-2-infected patients (aCOV) and 44 age-matched healthy controls
(Con) were included. Blood of aCOV was sampled at admission (T0), and at
day 2 (T2), day 5 (T5), day 10 (T10), and day 30 (T30) while blood of
Con was only sampled once. Inter- and intra-group differences were
calculated for hematological and hemorheological parameters. Except for
mean cellular volume and mean cellular hemoglobin, all blood cell
parameters were significantly different between aCOV and Con. During the
acute disease state (T0–T5), hematological and hemorheological
parameters were highly altered in aCOV; in particular, anemic conditions
and increased immune cell response/inflammation, oxidative/nitrosative
stress, decreased deformability, as well as increased aggregation, were
observed. During treatment and convalescence until T30, almost all
abnormal values of aCOV improved towards Con values. During the acute
state of the COVID-19 disease, the hematological, as well as the
hemorheological system, show fast and potentially pathological changes
that might contribute to the progression of the disease, but changes
appear to be largely reversible after four weeks. Measuring RBC
deformability and aggregation, as well as oxidative stress induction,
may be helpful in monitoring critically ill COVID-19 patients.
KW - Humans
KW - Hemorheology
KW - SARS-CoV-2
KW - COVID-19
KW - Hematology
KW - Erythrocyte Indices
KW - Critical Illness
KW - Erythrocyte Aggregation
U2 - 10.3390/ijms232315332
DO - 10.3390/ijms232315332
M3 - Journal articles
C2 - 36499657
SN - 1422-0067
VL - 23
SP - 1
EP - 17
JO - International journal of molecular sciences
JF - International journal of molecular sciences
IS - 23
M1 - 15332
ER -