Analysis of confiscated products with suspiciously doping relevant ingredients by GC-MS, LC-HRMS and LC-MSn

Oliver Krug; Andreas Thomas; Katja Walpurgis; Gerd Sigmund; Wilhelm Schänzer; Mario Thevis

Analysis of confiscated products with suspiciously doping relevant ingredients by GC-MS, LC-HRMS and LC-MSn

Oliver Krug, Andreas Thomas, Katja Walpurgis, Gerd Sigmund, Wilhelm Schänzer, Mario Thevis

Publication: Chapter in Book/Report/Conference proceeding › Conference contribution - Article for conference › Research

Abstract

The summary of analytical results of forty seven confiscated black-market products in 2011 is presented. Different formulations (oily solutions, tablets, and powders) in labeled and unlabeled packages were dissolved or extracted and diluted followed by measurements conducted with LC-MSn, LC-HRMS, and GC-MS. Thirty nine products showed 21 doping-relevant ingredients, furthermore labeled and identified drugs matched in only 25% of all cases. Additionally nearly half of the products contained non-declared doping-relevant drugs in trace amounts. An appreciable challenge was the identification of a phosphorylated compound, which was identified as Coenzyme A (CoA). Verf.-Referat

Original language	German
Title of host publication	Recent advances in doping analysis (20) : Proceedings of the Manfred-Donike-Workshop, 30th Cologne Workshop on Dope Analysis : 26th February to 2nd March 2012 2. Variante
Editors	Wilhelm Schänzer, Mario Thevis, Hans Geyer, Ute Mareck
Number of pages	3
Publisher	Sportverlag Strauß
Publication date	2012
Pages	132-134
Publication status	Published - 2012
Event	Cologne Workshop on Dope Analysis - Köln, Germany Duration: 26.02.2012 → 02.03.2012 Conference number: 30

Citation

Krug, O., Thomas, A., Walpurgis, K., Sigmund, G., Schänzer, W., & Thevis, M. (2012). Analysis of confiscated products with suspiciously doping relevant ingredients by GC-MS, LC-HRMS and LC-MSn. In W. Schänzer, M. Thevis, H. Geyer, & U. Mareck (Eds.), Recent advances in doping analysis (20) : Proceedings of the Manfred-Donike-Workshop, 30th Cologne Workshop on Dope Analysis : 26th February to 2nd March 2012 2. Variante (pp. 132-134). (Recent advances in doping analysis; Vol. 20). Sportverlag Strauß.

Krug, Oliver ; Thomas, Andreas ; Walpurgis, Katja et al. / Analysis of confiscated products with suspiciously doping relevant ingredients by GC-MS, LC-HRMS and LC-MSn. Recent advances in doping analysis (20) : Proceedings of the Manfred-Donike-Workshop, 30th Cologne Workshop on Dope Analysis : 26th February to 2nd March 2012 2. Variante. editor / Wilhelm Schänzer ; Mario Thevis ; Hans Geyer ; Ute Mareck. Sportverlag Strauß, 2012. pp. 132-134 (Recent advances in doping analysis).

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title = "Analysis of confiscated products with suspiciously doping relevant ingredients by GC-MS, LC-HRMS and LC-MSn",

abstract = "The summary of analytical results of forty seven confiscated black-market products in 2011 is presented. Different formulations (oily solutions, tablets, and powders) in labeled and unlabeled packages were dissolved or extracted and diluted followed by measurements conducted with LC-MSn, LC-HRMS, and GC-MS. Thirty nine products showed 21 doping-relevant ingredients, furthermore labeled and identified drugs matched in only 25% of all cases. Additionally nearly half of the products contained non-declared doping-relevant drugs in trace amounts. An appreciable challenge was the identification of a phosphorylated compound, which was identified as Coenzyme A (CoA). Verf.-Referat",

keywords = "Biochemie, Deutschland, Doping, Dopinganalyse, Dopingnachweis, Fl{\"u}ssigkeitschromatographie, Gaschromatographie, Massenspektrometrie, Nahrungserg{\"a}nzungsmittel, {\"O}strogen, Steroid, Stimulans",

author = "Oliver Krug and Andreas Thomas and Katja Walpurgis and Gerd Sigmund and Wilhelm Sch{\"a}nzer and Mario Thevis",

year = "2012",

language = "Deutsch",

series = "Recent advances in doping analysis",

publisher = "Sportverlag Strau{\ss}",

pages = "132--134",

editor = "Wilhelm Sch{\"a}nzer and Mario Thevis and Hans Geyer and Ute Mareck",

booktitle = "Recent advances in doping analysis (20) : Proceedings of the Manfred-Donike-Workshop, 30th Cologne Workshop on Dope Analysis : 26th February to 2nd March 2012 2. Variante",

note = "Cologne Workshop on Dope Analysis ; Conference date: 26-02-2012 Through 02-03-2012",

}

Krug, O , Thomas, A , Walpurgis, K, Sigmund, G, Schänzer, W & Thevis, M 2012, Analysis of confiscated products with suspiciously doping relevant ingredients by GC-MS, LC-HRMS and LC-MSn. in W Schänzer, M Thevis, H Geyer & U Mareck (eds), Recent advances in doping analysis (20) : Proceedings of the Manfred-Donike-Workshop, 30th Cologne Workshop on Dope Analysis : 26th February to 2nd March 2012 2. Variante. Recent advances in doping analysis, vol. 20, Sportverlag Strauß, pp. 132-134, Cologne Workshop on Dope Analysis, Köln, Germany, 26.02.12.

Analysis of confiscated products with suspiciously doping relevant ingredients by GC-MS, LC-HRMS and LC-MSn. / Krug, Oliver ; Thomas, Andreas ; Walpurgis, Katja et al.
Recent advances in doping analysis (20) : Proceedings of the Manfred-Donike-Workshop, 30th Cologne Workshop on Dope Analysis : 26th February to 2nd March 2012 2. Variante. ed. / Wilhelm Schänzer; Mario Thevis; Hans Geyer; Ute Mareck. Sportverlag Strauß, 2012. p. 132-134 (Recent advances in doping analysis; Vol. 20).

Publication: Chapter in Book/Report/Conference proceeding › Conference contribution - Article for conference › Research

TY - CHAP

T1 - Analysis of confiscated products with suspiciously doping relevant ingredients by GC-MS, LC-HRMS and LC-MSn

AU - Krug, Oliver

AU - Thomas, Andreas

AU - Walpurgis, Katja

AU - Sigmund, Gerd

AU - Schänzer, Wilhelm

AU - Thevis, Mario

N1 - Conference code: 30

PY - 2012

Y1 - 2012

N2 - The summary of analytical results of forty seven confiscated black-market products in 2011 is presented. Different formulations (oily solutions, tablets, and powders) in labeled and unlabeled packages were dissolved or extracted and diluted followed by measurements conducted with LC-MSn, LC-HRMS, and GC-MS. Thirty nine products showed 21 doping-relevant ingredients, furthermore labeled and identified drugs matched in only 25% of all cases. Additionally nearly half of the products contained non-declared doping-relevant drugs in trace amounts. An appreciable challenge was the identification of a phosphorylated compound, which was identified as Coenzyme A (CoA). Verf.-Referat

AB - The summary of analytical results of forty seven confiscated black-market products in 2011 is presented. Different formulations (oily solutions, tablets, and powders) in labeled and unlabeled packages were dissolved or extracted and diluted followed by measurements conducted with LC-MSn, LC-HRMS, and GC-MS. Thirty nine products showed 21 doping-relevant ingredients, furthermore labeled and identified drugs matched in only 25% of all cases. Additionally nearly half of the products contained non-declared doping-relevant drugs in trace amounts. An appreciable challenge was the identification of a phosphorylated compound, which was identified as Coenzyme A (CoA). Verf.-Referat

KW - Biochemie

KW - Deutschland

KW - Doping

KW - Dopinganalyse

KW - Dopingnachweis

KW - Flüssigkeitschromatographie

KW - Gaschromatographie

KW - Massenspektrometrie

KW - Nahrungsergänzungsmittel

KW - Östrogen

KW - Steroid

KW - Stimulans

M3 - Konferenzbeitrag - Aufsatz in Konferenzband

T3 - Recent advances in doping analysis

SP - 132

EP - 134

BT - Recent advances in doping analysis (20) : Proceedings of the Manfred-Donike-Workshop, 30th Cologne Workshop on Dope Analysis : 26th February to 2nd March 2012 2. Variante

A2 - Schänzer, Wilhelm

A2 - Thevis, Mario

A2 - Geyer, Hans

A2 - Mareck, Ute

PB - Sportverlag Strauß

T2 - Cologne Workshop on Dope Analysis

Y2 - 26 February 2012 through 2 March 2012

ER -

Krug O , Thomas A , Walpurgis K, Sigmund G, Schänzer W , Thevis M. Analysis of confiscated products with suspiciously doping relevant ingredients by GC-MS, LC-HRMS and LC-MSn. In Schänzer W, Thevis M, Geyer H, Mareck U, editors, Recent advances in doping analysis (20) : Proceedings of the Manfred-Donike-Workshop, 30th Cologne Workshop on Dope Analysis : 26th February to 2nd March 2012 2. Variante. Sportverlag Strauß. 2012. p. 132-134. (Recent advances in doping analysis).