Analytical detection of trimetazidine produced by metabolic conversion of lomerizine in doping control analysis

Masato Okano; Mario Thevis; Mitsuhiko Sato; Shinji Kageyama

doi:10.1002/dta.1893

Analytical detection of trimetazidine produced by metabolic conversion of lomerizine in doping control analysis

Masato Okano, Mario Thevis, Mitsuhiko Sato, Shinji Kageyama

Centre for Preventive Doping Research (ZePräDo)

Publication: Contribution to journal › Journal articles › Research › peer-review

Abstract

The identification of trimetazidine in urine samples might result from administration of the permitted drug lomerizine. Laboratories are therefore urged to carefully investigate suspicious cases where trimetazidine is detected. Differentiation of abuse of the banned substance trimetazidine from use of the permitted drug lomerizine would be supported by analysis of the intact drug lomerizine and/or specific metabolites.

Original language	English
Journal	Drug testing and analysis
ISSN	1942-7603
DOIs	https://doi.org/10.1002/dta.1893
Publication status	Published - 11.11.2015

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title = "Analytical detection of trimetazidine produced by metabolic conversion of lomerizine in doping control analysis",

abstract = "The identification of trimetazidine in urine samples might result from administration of the permitted drug lomerizine. Laboratories are therefore urged to carefully investigate suspicious cases where trimetazidine is detected. Differentiation of abuse of the banned substance trimetazidine from use of the permitted drug lomerizine would be supported by analysis of the intact drug lomerizine and/or specific metabolites.",

author = "Masato Okano and Mario Thevis and Mitsuhiko Sato and Shinji Kageyama",

note = "Copyright {\textcopyright} 2015 John Wiley & Sons, Ltd.",

year = "2015",

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day = "11",

doi = "10.1002/dta.1893",

language = "English",

journal = "Drug testing and analysis",

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T1 - Analytical detection of trimetazidine produced by metabolic conversion of lomerizine in doping control analysis

AU - Okano, Masato

AU - Thevis, Mario

AU - Sato, Mitsuhiko

AU - Kageyama, Shinji

PY - 2015/11/11

Y1 - 2015/11/11

N2 - The identification of trimetazidine in urine samples might result from administration of the permitted drug lomerizine. Laboratories are therefore urged to carefully investigate suspicious cases where trimetazidine is detected. Differentiation of abuse of the banned substance trimetazidine from use of the permitted drug lomerizine would be supported by analysis of the intact drug lomerizine and/or specific metabolites.

AB - The identification of trimetazidine in urine samples might result from administration of the permitted drug lomerizine. Laboratories are therefore urged to carefully investigate suspicious cases where trimetazidine is detected. Differentiation of abuse of the banned substance trimetazidine from use of the permitted drug lomerizine would be supported by analysis of the intact drug lomerizine and/or specific metabolites.

U2 - 10.1002/dta.1893

DO - 10.1002/dta.1893

M3 - Journal articles

C2 - 26560081

SN - 1942-7603

JO - Drug testing and analysis

JF - Drug testing and analysis

ER -

Analytical detection of trimetazidine produced by metabolic conversion of lomerizine in doping control analysis

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