Ca2+-dependent regulations and signaling in skeletal muscle: from electro-mechanical coupling to adaptation

Publication: Contribution to journalJournal articlesResearchpeer-review


Calcium (Ca2+) plays a pivotal role in almost all cellular processes and ensures the functionality of an organism. In skeletal muscle fibers, Ca(2+) is critically involved in the innervation of skeletal muscle fibers that results in the exertion of an action potential along the muscle fiber membrane, the prerequisite for skeletal muscle contraction. Furthermore and among others, Ca(2+) regulates also intracellular processes, such as myosin-actin cross bridging, protein synthesis, protein degradation and fiber type shifting by the control of Ca(2+)-sensitive proteases and transcription factors, as well as mitochondrial adaptations, plasticity and respiration. These data highlight the overwhelming significance of Ca(2+) ions for the integrity of skeletal muscle tissue. In this review, we address the major functions of Ca(2+) ions in adult muscle but also highlight recent findings of critical Ca(2+)-dependent mechanisms essential for skeletal muscle-regulation and maintenance.

Original languageEnglish
JournalInternational journal of molecular sciences
Issue number1
Pages (from-to)1066-1095
Number of pages30
Publication statusPublished - 2015

Research areas and keywords

  • Calcium
  • Excitation Contraction Coupling
  • Humans
  • Mitochondria
  • Muscle, Skeletal
  • Ryanodine Receptor Calcium Release Channel
  • Sarcoplasmic Reticulum Calcium-Transporting ATPases
  • Signal Transduction
  • Transcription Factors


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