Cardiovascular regulation - associations between exercise and head up tilt

Jessica Koschate, Uwe Drescher, Andreas Werner, Lutz Thieschäfer, Uwe Hoffmann

Publication: Contribution to journalJournal articlesResearchpeer-review


It was hypothesized that faster cardiorespiratory kinetics during exercise are associated with higher orthostatic tolerance. Cardiorespiratory kinetics of 14 healthy male subjects (30 ± 4 years, 179 ± 8 cm, 79 ± 8 kg) were tested on a cycle ergometer during exercise with changing work rates of 30 and 80 W. Pulmonary oxygen uptake (V O2pulm) was measured breath-by-breath and heart rate (HR), mean arterial blood pressure (MAP), and total peripheral resistance (TPR) were measured beat-to-beat. Muscular oxygen uptake (V O2musc) was estimated from HR and V O2pulm. Kinetic parameters were determined by time-series analysis, using cross-correlation functions (CCFmax(x)) between the parameter and the work rate. Cardiovascular regulations of MAP, HR, and TPR during orthostatic stress were measured beat-to-beat on a tilt seat. Changes between the minima and maxima during the 6° head-down tilt and the 90° head-up tilt positions were calculated for each parameter (Δtilt-up). CCFmax(V O2musc) correlated significantly with ΔTPRtilt-up (r = 0.790, p ≤ 0.001). CCFmax(HR) was significantly correlated with ΔHRtilt-up (r = –0.705, p = 0.002) and the amplitude in HR from 30 to 80 W (rSP = –0.574, p = 0.016). The observed correlations between cardiorespiratory regulation in response to exercise and orthostatic stress during rest might allow for a more differential analysis of the underlying mechanisms of orthostatic intolerance in, for example, patient groups.
Original languageEnglish
JournalCanadian journal of physiology and pharmacology
Issue number8
Pages (from-to)738-745
Number of pages8
Publication statusPublished - 08.2019


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