Changes in Hematological and Hemorheological Parameters Following Mild COVID-19: A 4-Month Follow-Up Study

Janina Bros; Lars Ibershoff; Emily Zollmann; Jonas Zacher; Fabian Tomschi; Hans-Georg Predel; Wilhelm Bloch; Marijke Grau

doi:10.3390/hematolrep15040057

Changes in Hematological and Hemorheological Parameters Following Mild COVID-19: A 4-Month Follow-Up Study

Janina Bros, Lars Ibershoff, Emily Zollmann, Jonas Zacher, Fabian Tomschi, Hans-Georg Predel, Wilhelm Bloch, Marijke Grau

German Sport University Cologne

Publication: Contribution to journal › Journal articles › Research › peer-review

Abstract

BACKGROUND: Coronavirus Disease 2019 (COVID-19) was described to affect red blood cells (RBC) in both severe and mild disease courses. The aim of this study was to investigate whether hematological and hemorheological changes that were previously described for COVID-19 patients after the acute infection state are still prominent after another 4 months to assess potential long-term effects.

METHODS: Hematological and RBC rheological parameters, including deformability and aggregation, were measured 41 days after infection in COVID-19 patients and non-COVID control (T0) and 4 months later in COVID-19 patients (T1).

RESULTS: The data confirm alterations in hematological parameters, mainly related to cell volume and hemoglobin concentration, but also reduced deformability and increased aggregation at T0 compared to control. While RBC deformability seems to have recovered, hemoglobin-related parameters and RBC aggregation were still impaired at T1. The changes were thus more pronounced in male COVID-19 patients.

CONCLUSION: COVID-19-related changes of the RBC partly consist of several months and might be related to persistent symptoms reported by many COVID-19 patients.

Original language	English
Journal	Hematology reports
Volume	15
Issue number	4
Pages (from-to)	543-554
Number of pages	12
ISSN	2038-8322
DOIs	https://doi.org/10.3390/hematolrep15040057
Publication status	Published - 10.10.2023

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title = "Changes in Hematological and Hemorheological Parameters Following Mild COVID-19: A 4-Month Follow-Up Study",

abstract = "BACKGROUND: Coronavirus Disease 2019 (COVID-19) was described to affect red blood cells (RBC) in both severe and mild disease courses. The aim of this study was to investigate whether hematological and hemorheological changes that were previously described for COVID-19 patients after the acute infection state are still prominent after another 4 months to assess potential long-term effects.METHODS: Hematological and RBC rheological parameters, including deformability and aggregation, were measured 41 days after infection in COVID-19 patients and non-COVID control (T0) and 4 months later in COVID-19 patients (T1).RESULTS: The data confirm alterations in hematological parameters, mainly related to cell volume and hemoglobin concentration, but also reduced deformability and increased aggregation at T0 compared to control. While RBC deformability seems to have recovered, hemoglobin-related parameters and RBC aggregation were still impaired at T1. The changes were thus more pronounced in male COVID-19 patients.CONCLUSION: COVID-19-related changes of the RBC partly consist of several months and might be related to persistent symptoms reported by many COVID-19 patients.",

author = "Janina Bros and Lars Ibershoff and Emily Zollmann and Jonas Zacher and Fabian Tomschi and Hans-Georg Predel and Wilhelm Bloch and Marijke Grau",

year = "2023",

month = oct,

day = "10",

doi = "10.3390/hematolrep15040057",

language = "English",

volume = "15",

pages = "543--554",

journal = "Hematology reports",

issn = "2038-8322",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "4",

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TY - JOUR

T1 - Changes in Hematological and Hemorheological Parameters Following Mild COVID-19

T2 - A 4-Month Follow-Up Study

AU - Bros, Janina

AU - Ibershoff, Lars

AU - Zollmann, Emily

AU - Zacher, Jonas

AU - Tomschi, Fabian

AU - Predel, Hans-Georg

AU - Bloch, Wilhelm

AU - Grau, Marijke

PY - 2023/10/10

Y1 - 2023/10/10

N2 - BACKGROUND: Coronavirus Disease 2019 (COVID-19) was described to affect red blood cells (RBC) in both severe and mild disease courses. The aim of this study was to investigate whether hematological and hemorheological changes that were previously described for COVID-19 patients after the acute infection state are still prominent after another 4 months to assess potential long-term effects.METHODS: Hematological and RBC rheological parameters, including deformability and aggregation, were measured 41 days after infection in COVID-19 patients and non-COVID control (T0) and 4 months later in COVID-19 patients (T1).RESULTS: The data confirm alterations in hematological parameters, mainly related to cell volume and hemoglobin concentration, but also reduced deformability and increased aggregation at T0 compared to control. While RBC deformability seems to have recovered, hemoglobin-related parameters and RBC aggregation were still impaired at T1. The changes were thus more pronounced in male COVID-19 patients.CONCLUSION: COVID-19-related changes of the RBC partly consist of several months and might be related to persistent symptoms reported by many COVID-19 patients.

AB - BACKGROUND: Coronavirus Disease 2019 (COVID-19) was described to affect red blood cells (RBC) in both severe and mild disease courses. The aim of this study was to investigate whether hematological and hemorheological changes that were previously described for COVID-19 patients after the acute infection state are still prominent after another 4 months to assess potential long-term effects.METHODS: Hematological and RBC rheological parameters, including deformability and aggregation, were measured 41 days after infection in COVID-19 patients and non-COVID control (T0) and 4 months later in COVID-19 patients (T1).RESULTS: The data confirm alterations in hematological parameters, mainly related to cell volume and hemoglobin concentration, but also reduced deformability and increased aggregation at T0 compared to control. While RBC deformability seems to have recovered, hemoglobin-related parameters and RBC aggregation were still impaired at T1. The changes were thus more pronounced in male COVID-19 patients.CONCLUSION: COVID-19-related changes of the RBC partly consist of several months and might be related to persistent symptoms reported by many COVID-19 patients.

U2 - 10.3390/hematolrep15040057

DO - 10.3390/hematolrep15040057

M3 - Journal articles

C2 - 37873792

SN - 2038-8322

VL - 15

SP - 543

EP - 554

JO - Hematology reports

JF - Hematology reports

IS - 4

ER -

Changes in Hematological and Hemorheological Parameters Following Mild COVID-19: A 4-Month Follow-Up Study

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