Comparison of different breath-by-breath gas exchange algorithms using a Gas Exchange Simulation System

Maria Pia Francescato; Lutz Thieschäfer; Valentina Cettolo; Uwe Hoffmann

doi:10.1016/j.resp.2019.04.009

Comparison of different breath-by-breath gas exchange algorithms using a Gas Exchange Simulation System

Maria Pia Francescato, Lutz Thieschäfer, Valentina Cettolo, Uwe Hoffmann

Forschungsgruppe Leistungsphysiologie

Department of Medicine, University of Udine, p.le Kolbe 4, Udine, Italy. Electronic address: mariapia.francescato@uniud.it.
Department of Medicine, University of Udine, p.le Kolbe 4, Udine, Italy.

Publication: Contribution to journal › Journal articles › Research › peer-review

Abstract

BACKGROUND: Mechanical Gas Exchange Simulation Systems (GESS) have never been used to compare different breath-by-breath oxygen uptake calculation algorithms.

METHODS: Oxygen uptakes were calculated for each GESS cycle by the "Expiration-only" algorithm (estimating inspiratory volume from the expiratory one), and by two "alveolar" algorithms (both processing inspiratory and expiratory flows and designed to account for the changes in lung gas stores). The volume of oxygen stored in the GESS from one cycle to the subsequent one was either maintained constant or increased/decreased by changing the pumped gas volumes.

RESULTS: Overlapping oxygen uptakes were obtained maintaining constant the volume of oxygen stored (grand average: 0.420 ± 0.019 L/min, p = ns). The "Expiration-only" algorithm overestimated the decreases of the stored oxygen by 34%, whereas the "alveolar" algorithms underestimated the increases by 25%; in the other conditions, the changes of the stored oxygen were appropriately accounted for.

CONCLUSIONS: The use of "alveolar" algorithms is recommended, particularly so when abrupt changes in the stored oxygen volume occur.

Original language	English
Journal	Respiratory Physiology & Neurobiology
Volume	266
Issue number	266
Pages (from-to)	171-178
Number of pages	8
ISSN	1878-1519
DOIs	https://doi.org/10.1016/j.resp.2019.04.009
Publication status	Published - 01.08.2019

Research areas and keywords

Journal Article
Algorithms
Models, Biological
Humans
Oxygen Consumption
Pulmonary Alveoli
Pulmonary Gas Exchange

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10.1016/j.resp.2019.04.009

Citation

@article{e9621c1f63da42dd8eec7ac462361416,

title = "Comparison of different breath-by-breath gas exchange algorithms using a Gas Exchange Simulation System",

abstract = "BACKGROUND: Mechanical Gas Exchange Simulation Systems (GESS) have never been used to compare different breath-by-breath oxygen uptake calculation algorithms.METHODS: Oxygen uptakes were calculated for each GESS cycle by the {"}Expiration-only{"} algorithm (estimating inspiratory volume from the expiratory one), and by two {"}alveolar{"} algorithms (both processing inspiratory and expiratory flows and designed to account for the changes in lung gas stores). The volume of oxygen stored in the GESS from one cycle to the subsequent one was either maintained constant or increased/decreased by changing the pumped gas volumes.RESULTS: Overlapping oxygen uptakes were obtained maintaining constant the volume of oxygen stored (grand average: 0.420 ± 0.019 L/min, p = ns). The {"}Expiration-only{"} algorithm overestimated the decreases of the stored oxygen by 34%, whereas the {"}alveolar{"} algorithms underestimated the increases by 25%; in the other conditions, the changes of the stored oxygen were appropriately accounted for.CONCLUSIONS: The use of {"}alveolar{"} algorithms is recommended, particularly so when abrupt changes in the stored oxygen volume occur.",

keywords = "Journal Article, Algorithms, Models, Biological, Humans, Oxygen Consumption, Pulmonary Alveoli, Pulmonary Gas Exchange, Breath-by-breath calculation algorithms, Gas exchange, Gas stores, Thermodynamic conversions",

author = "Francescato, {Maria Pia} and Lutz Thiesch{\"a}fer and Valentina Cettolo and Uwe Hoffmann",

year = "2019",

month = aug,

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doi = "10.1016/j.resp.2019.04.009",

language = "English",

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journal = "Respiratory Physiology & Neurobiology",

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T1 - Comparison of different breath-by-breath gas exchange algorithms using a Gas Exchange Simulation System

AU - Francescato, Maria Pia

AU - Thieschäfer, Lutz

AU - Cettolo, Valentina

AU - Hoffmann, Uwe

PY - 2019/8/1

Y1 - 2019/8/1

N2 - BACKGROUND: Mechanical Gas Exchange Simulation Systems (GESS) have never been used to compare different breath-by-breath oxygen uptake calculation algorithms.METHODS: Oxygen uptakes were calculated for each GESS cycle by the "Expiration-only" algorithm (estimating inspiratory volume from the expiratory one), and by two "alveolar" algorithms (both processing inspiratory and expiratory flows and designed to account for the changes in lung gas stores). The volume of oxygen stored in the GESS from one cycle to the subsequent one was either maintained constant or increased/decreased by changing the pumped gas volumes.RESULTS: Overlapping oxygen uptakes were obtained maintaining constant the volume of oxygen stored (grand average: 0.420 ± 0.019 L/min, p = ns). The "Expiration-only" algorithm overestimated the decreases of the stored oxygen by 34%, whereas the "alveolar" algorithms underestimated the increases by 25%; in the other conditions, the changes of the stored oxygen were appropriately accounted for.CONCLUSIONS: The use of "alveolar" algorithms is recommended, particularly so when abrupt changes in the stored oxygen volume occur.

AB - BACKGROUND: Mechanical Gas Exchange Simulation Systems (GESS) have never been used to compare different breath-by-breath oxygen uptake calculation algorithms.METHODS: Oxygen uptakes were calculated for each GESS cycle by the "Expiration-only" algorithm (estimating inspiratory volume from the expiratory one), and by two "alveolar" algorithms (both processing inspiratory and expiratory flows and designed to account for the changes in lung gas stores). The volume of oxygen stored in the GESS from one cycle to the subsequent one was either maintained constant or increased/decreased by changing the pumped gas volumes.RESULTS: Overlapping oxygen uptakes were obtained maintaining constant the volume of oxygen stored (grand average: 0.420 ± 0.019 L/min, p = ns). The "Expiration-only" algorithm overestimated the decreases of the stored oxygen by 34%, whereas the "alveolar" algorithms underestimated the increases by 25%; in the other conditions, the changes of the stored oxygen were appropriately accounted for.CONCLUSIONS: The use of "alveolar" algorithms is recommended, particularly so when abrupt changes in the stored oxygen volume occur.

KW - Journal Article

KW - Algorithms

KW - Models, Biological

KW - Humans

KW - Oxygen Consumption

KW - Pulmonary Alveoli

KW - Pulmonary Gas Exchange

KW - Breath-by-breath calculation algorithms

KW - Gas exchange

KW - Gas stores

KW - Thermodynamic conversions

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JO - Respiratory Physiology & Neurobiology

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ER -

Comparison of different breath-by-breath gas exchange algorithms using a Gas Exchange Simulation System

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