Detection of meclofenoxate and its degradation products Dimethylaminoethanol and p-chloro-phenoxyacetic acid

Publication: Chapter in Book/Report/Conference proceedingConference contribution - Article for conferenceResearch


As described in literature meclofenoxate is rapidly hydrolysed to DMAE and 4-CPA under physiological conditions. This was confirmed with the present study enabling only the detection of degradation products in post administration samples of meclofenoxate. The presence of 4-CPA in human urine is originating possibly from an oral intake of herbicide residues with food. The substance is utilized as a herbicide and growth regulator for plants. 4- CPA is considered to be absorbed completely from an oral dose and is eliminated rapidly unchanged in the urine. The second degradation product DMAE as a nootropic substance is produced naturally in the human brain and is available as a nutritional supplement. Frequent detection of 4-CPA in urine and the fact that DMAE occurs physiologically in the human body demonstrates the difficulty of sufficient screening for meclofenoxate. Hence an unambiguous proof of meclofenoxate misuse by identification of its degradation products requires further investigation. Aus dem Text (geändert)
Original languageGerman
Title of host publicationRecent advances in doping analysis (14) : Proceedings of the Manfred Donike Workshop ; 24th Cologne Workshop on Dope Analysis 4th to 9th June 2006
EditorsWilhelm Schänzer, Hans Geyer, A. Gotzmann, Ute Mareck
Number of pages4
PublisherSport & Buch Strauß
Publication date2006
Publication statusPublished - 2006
EventCologne Workshop on Dope Analysis - Köln, Germany
Duration: 04.06.200609.06.2006
Conference number: 24