Effects of lymphatic drainage and cryotherapy on indirect markers of muscle damage

Publication: Contribution to journalJournal articlesResearchpeer-review


BACKGROUND: Muscle enzymes are cleared from the extracellular space by the lymphatic system, while smaller proteins enter the bloodstream directly. We investigated if manual lymphatic drainage (MLD), local cryotherapy (CRY), and rest (RST) differently affect the time course of creatine kinase (CK, 84 kDa) and heart-type fatty acid binding protein (h-FABP, 15 kDa) in the blood.

DESIGN: Randomized controlled trial.

METHODS: After 4x20 unilateral, eccentric accentuated knee extensions (with one-third of the maximal isometric force) 30 sports students randomly received either a 30 min MLD, CRY or they rested (RST) for the same amount of time. CK, h-FABP, neutrophil granulocytes, and the perceived muscle soreness were assessed before, immediately after, and 1 h, 4 h, and 24 h after the exercise.

RESULTS: All measures increased significantly (p<0.001) after the protocol indicating that muscle damage was induced. However, the responses did not differ between the treatments.

CONCLUSIONS: Large and small damage markers were not affected differently by MLD, CRY, or RST, when applied for 30 min and no beneficial effects on inflammation or muscle soreness could be found for MLD and CRY when compared to RST. This information is particularly important for those sports physicians and conditioning specialists who use biochemical muscle damage markers to adjust the training load and volume of athletes'.

Original languageEnglish
JournalThe Journal of sports medicine and physical fitness
Issue number6
Pages (from-to)903-909
Number of pages7
Publication statusPublished - 2018

Research areas and keywords

  • Journal Article


Dive into the research topics of 'Effects of lymphatic drainage and cryotherapy on indirect markers of muscle damage'. Together they form a unique fingerprint.