Einfluss von körperlichem Training auf die Homöostase von regulatorischen T-Zellen

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The strong influence of physical activity on health benefits is a matter of common knowledge. Since biological effects of physical activity are partly mediated through the amelioration of chronic inflammation, the impact of physical activity on the number of regulatory T cells, the central regulators of adaptive immunity and inflammation, requires further investigations. To determine whether there is a causal relation between physical activity and the number of regulatory T cells, blood samples from the German Olympic Hockey Team before and after a training camps were analysed. In the present study the number of regulatory T cells in athletes correlated with exercise intensity determined by the relative VO2peak, a measure of aerobic physical fitness. Physical exercise led to a significant increase in regulatory T cells. To summarize in can be noted, physical activity modulates regulatory T cell homeostasis in healthy individuals. These results suggest that intensity depending physical exercise, promotes anti-inflammatory immunity. Considering the large number of patients, suffering from chronic low-grade inflammation disease, a strong influence on clinical treatments should be taken into account. These outcomes highlight the importance of physical activity maintaining a healthy immune system balance and reinforce the role of physical exercise reducing chronical low-grade inflammation.
Original languageGerman
Place of PublicationKöln
PublisherDeutsche Sporthochschule Köln
Number of pages71
Publication statusPublished - 2017