Extrakorporale Stoßwellentherapie für die Regeneration der Skelettmuskulatur

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Abstract

Background: Extracorporeal shockwave therapy inter alia is applied to treat skeletal-muscle- and bone-traumatism. The underlying mechanisms of most positive effects are unknown so far. The aim of the study was to investigate whether shockwaves affect muscle oxygen supply which may be related to RBC-deformability and associated NO levels.
Method: 10.000 Shockwaves were applied (5 MPa-focus and 0.702 mJ/mm², 8Hz) on the muscle quadriceps femoris of 4 (n = 4, pilot-study), respectively 13 (n = 13, main-study) healthy male subjects. Further, shockwaves were ap-plied over pork-skin roofed blood-samples from 8 male subjects with condition 0 (control), 500, 1.000, 1.500 (n = 8, in-vitro-study).
Oxygen supply was measured Pre and Post (pilot-study), respectively Pre, Post 0‘, Post 10‘, Post 20‘ and Post 30‘ (main-study), by NIRS and venous blood was sampled Pre and 0h, 2h, 6h and 24h post intervention. RBC-deformability was determined by ektacytometry and nitrite concentrations in plasma and RBC, as a marker of RBC-NO production, by CLD, respectively. RBC-populations were determined 0h/6h post (in-vitro), by a percoll-solution. Af-terwards, thus deformability, weight and volume were determined.
Results: RBC and plasma nitrite levels decreased post intervention with lowest values measured 2h but increased back to pre-level 24h. RBC-deformability decreased with minimum values measured 6h and increased again 24h. In-vitro, shockwaves might not negatively affect RBC-populations and -structure and thus function. The tested shockwave protocol might negatively affect NO availability in RBC leading to reduced RBC-deformability but did not affect oxygenation of the muscles. Admittedly, further studies are needed.
Original languageGerman
Place of PublicationKöln
PublisherDeutsche Sporthochschule Köln
Number of pages111
Publication statusPublished - 2022

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