Hypoxia-inducible factor (HIF) pathway as target for doping purposes and mass spectrometric characterisation of orally available model HIF-stabilizers

S. Beuck, N. Schlörer, M. Kamber, Wilhelm Schänzer, Mario Thevis

Publication: Chapter in Book/Report/Conference proceedingConference contribution - Article for conferenceResearch

Abstract

Aiming at analytical method design, we studied the mass spectrometric dissociation behaviour of 5 isoquinoline-3-carboxamides that might potentially be clinically relevant HIF stabilisers according to literature data and patent specifications. Mass spectrometric information required for the development of analytical assays for HIF stabilisers with isoquinoline scaffold was gained by studying the collision induced dissociation behaviour of the five protonated model HIF-PHI 1 and 4-7. Herein, we exemplary discuss the CID of compound 1 in detail. Aus dem Text
Original languageEnglish
Title of host publicationRecent advances in doping analysis (17) : Proceedings of the Manfred Donike Workshop ; 27th Cologne Workshop on Dope Analysis, 1st to 6th March 2009
EditorsWilhelm Schänzer, Hans Geyer, A. Gotzmann, Ute Mareck
Number of pages10
PublisherSportverlag Strauß
Publication date2009
Pages155-164
Publication statusPublished - 2009
EventCologne Workshop on Dope Analysis - Köln, Germany
Duration: 01.03.200906.03.2009
Conference number: 27

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