Interhemispheric transfer time correlates with white matter integrity of the corpus callosum in healthy older adults

David Riedel*, Nicolai Lorke, Tim Fellerhof, Andreas Mierau, Heiko Klaus Strüder, Dominik Wolf, Florian U. Fischer, Andreas Fellgiebel, Oliver Tüscher, Bianca Kollmann, Kristel Knaepen

*Corresponding author for this work

Publication: Contribution to journalJournal articlesResearchpeer-review


The corpus callosum (CC) has been identified as an important structure in the context of cognitive aging (Fling et al., 2011). Interhemispheric transfer time (IHTT) is regularly used in order to estimate interhemispheric integration enabled by the CC (Marzi, 2010; Nowicka and Tacikowski, 2011). However, only little is known with regards to the relationship between IHTT and the structural properties of the CC with only few studies with specific samples and methods available (Whitford et al., 2011). Thus, the present study aimed at investigating this relationship applying an event-related potentials (ERP) based approach of estimating IHTT as well as diffusion weighted imaging (DWI) with fractional anisotropy (FA) as an indicator of white matter integrity (WMI) of the genu, corpus and splenium of the CC. 56 healthy older adults performed a Dimond Task while ERPs were recorded and underwent DWI scanning. IHTT derived from posterior electrode sites correlated significantly with FA of the splenium (r = −0.286*, p = .03) but not the corpus (r = −0.187, p = .08) or genu (r = −0.189, p = .18). The present results support the notion that IHTT is related to WMI of the posterior CC. It may be concluded that ERP based IHTT is a suitable indicator of CC structure and function, however, likely specific to the interhemispheric transfer of visual information. Future studies may wish to confirm these findings in a more divers sample further exploring the precise interrelation between IHTT and structural or functional properties of the CC.
Original languageEnglish
Article number108761
Publication statusPublished - 15.12.2023


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