Sclerostin and DKK1 levels during 14 and 21 days of bed rest in healthy young men

P Frings-Meuthen, G Boehme, A-M Liphardt, N Baecker, M Heer, J Rittweger

Publication: Contribution to journalJournal articlesResearchpeer-review

Abstract

OBJECTIVES: Wnt signaling pathway may be crucial in the pathogenesis of disuse-induced bone loss. Sclerostin and DKK1, antagonists of the Wnt signaling pathway, were assessed during immobilization by bed rest in young, healthy people.

METHODS: Two bed rest studies were conducted at the German Aerospace Center in Cologne. 14 days of 6° head-down-tilt bed rest were applied to eight healthy young male test subjects in study 1 and 21 days of head-down-tilt bed rest to seven healthy male subjects in study 2.

RESULTS: Sclerostin levels increased in both studies during bed rest (study 1, 0.64±0.05 ng/ml to 0.69±0.04 ng/ml, P=0.014; study 2, 0.42±0.04 ng/ml to 0.47±0.04 ng/ml, P=0.008) and they declined at the end of the 14- and 21-day bed rest periods. DKK1 decreased during the bed rest period in study 1 (P<0.001) but increased during bed rest in study 2 (P=0.006). As expected, bone formation marker PINP decreased (study 1, P=0.013; study 2, P<0.001) and bone resorption marker NTX increased during bed rest (P<0.001).

CONCLUSION: Data suggest that the Wnt signaling pathway is involved in disuse-induced bone loss in young, healthy humans.

Original languageEnglish
JournalJournal of musculoskeletal & neuronal interactions
Volume13
Issue number1
Pages (from-to)45-52
Number of pages8
ISSN1108-7161
Publication statusPublished - 01.03.2013

Research areas and keywords

  • Adult
  • Bed Rest
  • Biological Markers
  • Bone Morphogenetic Proteins
  • Bone Resorption
  • Cross-Over Studies
  • Down-Regulation
  • Genetic Markers
  • Head-Down Tilt
  • Humans
  • Intercellular Signaling Peptides and Proteins
  • Male
  • Up-Regulation
  • Young Adult

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