The detection of the misuse of testosterone gel

Publication: Chapter in Book/Report/Conference proceedingConference contribution - Article for conferenceResearch

Abstract

To develop a method for the detection of the misuse of testosterone gel (T-gel) 18 healthy male volunteers were treated for six weeks continuously and intermittently with T-gel (100 mg testosterone per day). Blood and urine samples were collected before, during and after the application of T-gel. The following results were obtained. The treatment with T-gel leads to an increase of serum testosterone and a decrease of LH. The most discriminating parameters of the steroid profile are the ratios testosterone/epitestosterone, 5α-androstane-3 α,17ß-diol / epitestosterone and androsterone/epitestosterone. Individual reference ranges of the parameters are more suitable for the detection of the misuse of T-gel than population based reference ranges. For the GC/C/IRMS analysis suitable target compounds are testosterone and 5α -androstane-3 α,17ß-diol. Verf.-Referat
Original languageEnglish
Title of host publicationRecent advances in doping analysis (15) : Proceedings of the Manfred Donike Workshop ; 25th Cologne Workshop on Dope Analysis 25th February to 2nd March 2007
EditorsWilhelm Schänzer, Hans Geyer, A. Gotzmann, Ute Mareck
Number of pages10
PublisherSportverlag Strauß
Publication date2007
Pages133-142
Publication statusPublished - 2007
EventCologne Workshop on Dope Analysis - Köln, Germany
Duration: 25.02.200702.03.2007
Conference number: 25

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