The intranasal AlaxoLito Plus Nasal Stent: Improvement of NO-induced microrheology and oxygen uptake during exercise?

Daniel A Bizjak; Peter Schams; Wilhelm Bloch; Marijke Grau; Joachim Latsch

doi:10.1016/j.resp.2019.103260

The intranasal AlaxoLito Plus Nasal Stent: Improvement of NO-induced microrheology and oxygen uptake during exercise?

Daniel A Bizjak, Peter Schams, Wilhelm Bloch, Marijke Grau, Joachim Latsch

Publication: Contribution to journal › Journal articles › Research › peer-review

Abstract

AIM: To investigate the influence of the intranasal AlaxoLito Plus Nasal Stent during exercise on nitric oxide (NO) synthesis, NO exhalation, red blood cell (RBC) deformability and oxygen uptake.

METHODS: Parameters were measured before and after acute cycle ergometer test at different intensities. Spirometric, microrheological and NO parameters were determined for oral (OB), nasal (NB) and nasal-stent breathing (SB). RBC deformability was measured and elongation indices for 3.87 Pa and maximal deformability were calculated. RBC/plasma/exhaled NO, oxygen uptake and respiratory rate were determined.

RESULTS: Exhaled NO was higher at rest during OB compared to SB and NB and decreased after exercise with NB and SB. Plasma and RBC NO remained unaltered during intervention. RBC deformability increased at moderate intensity during SB. Deformability decreased at moderate and medium intensity with NB. Respiratory rate for same oxygen uptake did not differ between breathing settings.

CONCLUSION: The AlaxoLito Plus Nasal Stent may modulate deformability during moderate exercise and increase NO exhalation without major effects on oxygen uptake and performance.

Original language	English
Journal	Respiratory Physiology & Neurobiology
Volume	269
Pages (from-to)	103260
ISSN	1878-1519
DOIs	https://doi.org/10.1016/j.resp.2019.103260
Publication status	Published - 01.11.2019

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title = "The intranasal AlaxoLito Plus Nasal Stent: Improvement of NO-induced microrheology and oxygen uptake during exercise?",

abstract = "AIM: To investigate the influence of the intranasal AlaxoLito Plus Nasal Stent during exercise on nitric oxide (NO) synthesis, NO exhalation, red blood cell (RBC) deformability and oxygen uptake.METHODS: Parameters were measured before and after acute cycle ergometer test at different intensities. Spirometric, microrheological and NO parameters were determined for oral (OB), nasal (NB) and nasal-stent breathing (SB). RBC deformability was measured and elongation indices for 3.87 Pa and maximal deformability were calculated. RBC/plasma/exhaled NO, oxygen uptake and respiratory rate were determined.RESULTS: Exhaled NO was higher at rest during OB compared to SB and NB and decreased after exercise with NB and SB. Plasma and RBC NO remained unaltered during intervention. RBC deformability increased at moderate intensity during SB. Deformability decreased at moderate and medium intensity with NB. Respiratory rate for same oxygen uptake did not differ between breathing settings.CONCLUSION: The AlaxoLito Plus Nasal Stent may modulate deformability during moderate exercise and increase NO exhalation without major effects on oxygen uptake and performance.",

keywords = "Breathing performance, Haemorheology, Nitric oxide metabolism, Stent application",

author = "Bizjak, {Daniel A} and Peter Schams and Wilhelm Bloch and Marijke Grau and Joachim Latsch",

year = "2019",

month = nov,

day = "1",

doi = "10.1016/j.resp.2019.103260",

language = "English",

volume = "269",

pages = "103260",

journal = "Respiratory Physiology & Neurobiology",

issn = "1878-1519",

publisher = "Elsevier",

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TY - JOUR

T1 - The intranasal AlaxoLito Plus Nasal Stent

T2 - Improvement of NO-induced microrheology and oxygen uptake during exercise?

AU - Bizjak, Daniel A

AU - Schams, Peter

AU - Bloch, Wilhelm

AU - Grau, Marijke

AU - Latsch, Joachim

PY - 2019/11/1

Y1 - 2019/11/1

N2 - AIM: To investigate the influence of the intranasal AlaxoLito Plus Nasal Stent during exercise on nitric oxide (NO) synthesis, NO exhalation, red blood cell (RBC) deformability and oxygen uptake.METHODS: Parameters were measured before and after acute cycle ergometer test at different intensities. Spirometric, microrheological and NO parameters were determined for oral (OB), nasal (NB) and nasal-stent breathing (SB). RBC deformability was measured and elongation indices for 3.87 Pa and maximal deformability were calculated. RBC/plasma/exhaled NO, oxygen uptake and respiratory rate were determined.RESULTS: Exhaled NO was higher at rest during OB compared to SB and NB and decreased after exercise with NB and SB. Plasma and RBC NO remained unaltered during intervention. RBC deformability increased at moderate intensity during SB. Deformability decreased at moderate and medium intensity with NB. Respiratory rate for same oxygen uptake did not differ between breathing settings.CONCLUSION: The AlaxoLito Plus Nasal Stent may modulate deformability during moderate exercise and increase NO exhalation without major effects on oxygen uptake and performance.

AB - AIM: To investigate the influence of the intranasal AlaxoLito Plus Nasal Stent during exercise on nitric oxide (NO) synthesis, NO exhalation, red blood cell (RBC) deformability and oxygen uptake.METHODS: Parameters were measured before and after acute cycle ergometer test at different intensities. Spirometric, microrheological and NO parameters were determined for oral (OB), nasal (NB) and nasal-stent breathing (SB). RBC deformability was measured and elongation indices for 3.87 Pa and maximal deformability were calculated. RBC/plasma/exhaled NO, oxygen uptake and respiratory rate were determined.RESULTS: Exhaled NO was higher at rest during OB compared to SB and NB and decreased after exercise with NB and SB. Plasma and RBC NO remained unaltered during intervention. RBC deformability increased at moderate intensity during SB. Deformability decreased at moderate and medium intensity with NB. Respiratory rate for same oxygen uptake did not differ between breathing settings.CONCLUSION: The AlaxoLito Plus Nasal Stent may modulate deformability during moderate exercise and increase NO exhalation without major effects on oxygen uptake and performance.

KW - Breathing performance

KW - Haemorheology

KW - Nitric oxide metabolism

KW - Stent application

UR - https://www.mendeley.com/catalogue/4c48af6a-81a1-3839-9b99-3865934215bb/

U2 - 10.1016/j.resp.2019.103260

DO - 10.1016/j.resp.2019.103260

M3 - Journal articles

C2 - 31352012

SN - 1878-1519

VL - 269

SP - 103260

JO - Respiratory Physiology & Neurobiology

JF - Respiratory Physiology & Neurobiology

ER -

The intranasal AlaxoLito Plus Nasal Stent: Improvement of NO-induced microrheology and oxygen uptake during exercise?

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