Unambiguous identification and characterization of a long-term human metabolite of dehydrochloromethyltestosterone

Guro Forsdahl, Thomas Geisendorfer, Lorenz Göschl, Sandra Pfeffer, Peter Gärtner, Mario Thevis, Günter Gmeiner

Publication: Contribution to journalJournal articlesResearchpeer-review

Abstract

In doping control analysis, the characterization of urinary steroid metabolites is of high interest for a targeted and long-term detection of prohibited anabolic androgenic steroids (AAS). In this work, the structure of a long-term metabolite of dehydrochloromethyltestosterone (DHCMT) was elucidated. Altogether, eight possible metabolites with a 17α-methyl-17β-hydroxymethyl - structure were synthesized and compared to a major DHCMT long-term metabolite detected in reference urine excretion samples. The confirmed structure of the metabolite was 4α-chloro-18-nor-17β-hydroxymethyl-17α-methyl-5α-androst-13-en-3α-ol.

Original languageEnglish
JournalDrug testing and analysis
Volume10
Issue number8
Pages (from-to)1244-1250
Number of pages7
ISSN1942-7603
DOIs
Publication statusPublished - 23.03.2018

Research areas and keywords

  • Journal Article

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