One of the main aims of my research is to investigate the regulatory mechanisms of red blood cell (RBC) function, in particular RBC deformability, and to examine its relevance in physiological and pathophysiological conditions. This includes basic cellular conditions but also the impact of blood storage and exercise interventions on structural and functional changes of RBC in general but also in athletes and patients suffering from various diseases (diabetes, sickle cell anemia). The outcome will help to develop strategies to improve hemorheology and clinical outcome.