Abstract
So far, NMR metabonomics showed its potential for a range of applications in medicine, biochemistry, drug development, nutrition and related disciplines. During a pilot study NMR metabonomics was used for the discrimination between pre- and post-administration urines of a single dose administration trial with testosterone undecanoate (Andriol®) in humans. Discrimination was possible for almost 48 hours applying non-targeted principal components analysis while it was possible even for two weeks using a refined data analysis. Another indirect detection technique for anabolic androgenic steroid abuse appears to be the analyses of pituitary profiles. The exogenous administration of anabolic steroids, including testosterone, is known to affect the production of endogenous hormones via feedback mechanisms on the hypothalamic pituitary gland axis. Within our investigation we have analyzed the effect of anabolics administration on different hormonal serum concentrations. Multiple doses were monitored and resulted in decreased LH and inhibin concentrations in rats. These findings were confirmed by samples collected from bodybuilders abusing steroids. Additionally the members of the “abuser” group were found to have significantly higher serum prolactin levels compared to normal males. Verf.-Referat
Originalsprache | Englisch |
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Titel | Recent advances in doping analysis (20) : Proceedings of the Manfred-Donike-Workshop, 30th Cologne Workshop on Dope Analysis : 26th February to 2nd March 2012 2. Variante |
Herausgeber*innen | Wilhelm Schänzer, Mario Thevis, Hans Geyer, Ute Mareck |
Seitenumfang | 6 |
Herausgeber (Verlag) | Sportverlag Strauß |
Erscheinungsdatum | 2012 |
Seiten | 46-51 |
Publikationsstatus | Veröffentlicht - 2012 |
Veranstaltung | Cologne Workshop on Dope Analysis - Köln, Deutschland Dauer: 26.02.2012 → 02.03.2012 Konferenznummer: 30 |
Fachgebiete und Schlagwörter
- Biochemie
- Doping
- Dopinganalyse
- Dopingnachweis
- Screening
- Steroid, anaboles
- Testosteron
- Untersuchungsmethode
- Urin
- Urinausscheidung
- Urinuntersuchung