Alternative detection strategies for anabolic steroid abuse by NMR metabonomics and endocrine feedback loop analyses

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So far, NMR metabonomics showed its potential for a range of applications in medicine, biochemistry, drug development, nutrition and related disciplines. During a pilot study NMR metabonomics was used for the discrimination between pre- and post-administration urines of a single dose administration trial with testosterone undecanoate (Andriol®) in humans. Discrimination was possible for almost 48 hours applying non-targeted principal components analysis while it was possible even for two weeks using a refined data analysis. Another indirect detection technique for anabolic androgenic steroid abuse appears to be the analyses of pituitary profiles. The exogenous administration of anabolic steroids, including testosterone, is known to affect the production of endogenous hormones via feedback mechanisms on the hypothalamic pituitary gland axis. Within our investigation we have analyzed the effect of anabolics administration on different hormonal serum concentrations. Multiple doses were monitored and resulted in decreased LH and inhibin concentrations in rats. These findings were confirmed by samples collected from bodybuilders abusing steroids. Additionally the members of the “abuser” group were found to have significantly higher serum prolactin levels compared to normal males. Verf.-Referat
OriginalspracheEnglisch
TitelRecent advances in doping analysis (20) : Proceedings of the Manfred-Donike-Workshop, 30th Cologne Workshop on Dope Analysis : 26th February to 2nd March 2012 2. Variante
Redakteure/-innenWilhelm Schänzer, Mario Thevis, Hans Geyer, Ute Mareck
Seitenumfang6
Herausgeber/inSportverlag Strauß
Erscheinungsdatum2012
Seiten46-51
PublikationsstatusVeröffentlicht - 2012
VeranstaltungCologne Workshop on Dope Analysis - Köln, Deutschland
Dauer: 26.02.201202.03.2012
Konferenznummer: 30

ID: 185885

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