Alternative steroid profiling : reference ranges for urinary endogenous steroids in a Caucasian population of athletes

P. van Renterghem; P. van Eenoo; Hans Geyer; Wilhelm Schänzer; F.T. Delbeke

Alternative steroid profiling : reference ranges for urinary endogenous steroids in a Caucasian population of athletes

P. van Renterghem, P. van Eenoo, Hans Geyer, Wilhelm Schänzer, F.T. Delbeke

Institut für Biochemie

Publikation: Beitrag in Buch/Bericht/Konferenzband › Konferenzbeitrag - Aufsatz in Konferenzband › Forschung

Abstract

A comprehensive screening method for steroid profiling was developed covering 29 steroid metabolites. Additionally, 10 steroid ratios were evaluated. Based upon a reference population of more than 3000 samples from healthy athletes the reference values were established at 3 different levels: 97.5%, 99% and 99.9%. Using the extended method and the reference ranges, 2 additional metabolites from 6-oxo-Adion were identified; 6ß-OH-Andro and 6ß-OH-Etio could stretch the detection time for 6-oxo-Adion administration until 36h. In the case of 7-keto-DHEA, 7α-OH-T can be regarded as additional specific metabolite. 7-keto-DHEA can be detected 36h after intake although steroid ratios indicate prolonged changes up to 48h of the steroid profile. Aus dem Text

Originalsprache	Deutsch
Titel	Recent advances in doping analysis (17) : Proceedings of the Manfred Donike Workshop ; 27th Cologne Workshop on Dope Analysis, 1st to 6th March 2009
Herausgeber*innen	Wilhelm Schänzer, Hans Geyer, A. Gotzmann, Ute Mareck
Seitenumfang	10
Herausgeber (Verlag)	Sportverlag Strauß
Erscheinungsdatum	2009
Seiten	81-90
Publikationsstatus	Veröffentlicht - 2009
Veranstaltung	Cologne Workshop on Dope Analysis - Köln, Deutschland Dauer: 01.03.2009 → 06.03.2009 Konferenznummer: 27

Fachgebiete und Schlagwörter

Biochemie
Doping
Dopinganalyse
Dopingnachweis
Gaschromatographie
Massenspektrometrie
Screening
Sportmedizin
Steroid
Untersuchungsmethode
Urinausscheidung
Urinuntersuchung

Zitation

Renterghem, P. V., Eenoo, P. V., Geyer, H., Schänzer, W., & Delbeke, F. T. (2009). Alternative steroid profiling : reference ranges for urinary endogenous steroids in a Caucasian population of athletes. in W. Schänzer, H. Geyer, A. Gotzmann, & U. Mareck (Hrsg.), Recent advances in doping analysis (17) : Proceedings of the Manfred Donike Workshop ; 27th Cologne Workshop on Dope Analysis, 1st to 6th March 2009 (S. 81-90). (Recent advances in doping analysis; Band 17). Sportverlag Strauß.

Renterghem, P. van ; Eenoo, P. van ; Geyer, Hans et al. / Alternative steroid profiling : reference ranges for urinary endogenous steroids in a Caucasian population of athletes. Recent advances in doping analysis (17) : Proceedings of the Manfred Donike Workshop ; 27th Cologne Workshop on Dope Analysis, 1st to 6th March 2009. Hrsg. / Wilhelm Schänzer ; Hans Geyer ; A. Gotzmann ; Ute Mareck. Sportverlag Strauß, 2009. S. 81-90 (Recent advances in doping analysis).

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title = "Alternative steroid profiling : reference ranges for urinary endogenous steroids in a Caucasian population of athletes",

abstract = "A comprehensive screening method for steroid profiling was developed covering 29 steroid metabolites. Additionally, 10 steroid ratios were evaluated. Based upon a reference population of more than 3000 samples from healthy athletes the reference values were established at 3 different levels: 97.5%, 99% and 99.9%. Using the extended method and the reference ranges, 2 additional metabolites from 6-oxo-Adion were identified; 6{\ss}-OH-Andro and 6{\ss}-OH-Etio could stretch the detection time for 6-oxo-Adion administration until 36h. In the case of 7-keto-DHEA, 7α-OH-T can be regarded as additional specific metabolite. 7-keto-DHEA can be detected 36h after intake although steroid ratios indicate prolonged changes up to 48h of the steroid profile. Aus dem Text",

keywords = "Biochemie, Doping, Dopinganalyse, Dopingnachweis, Gaschromatographie, Massenspektrometrie, Screening, Sportmedizin, Steroid, Untersuchungsmethode, Urinausscheidung, Urinuntersuchung",

author = "Renterghem, {P. van} and Eenoo, {P. van} and Hans Geyer and Wilhelm Sch{\"a}nzer and F.T. Delbeke",

year = "2009",

language = "Deutsch",

series = "Recent advances in doping analysis",

publisher = "Sportverlag Strau{\ss}",

pages = "81--90",

editor = "Wilhelm Sch{\"a}nzer and Hans Geyer and A. Gotzmann and Ute Mareck",

booktitle = "Recent advances in doping analysis (17) : Proceedings of the Manfred Donike Workshop ; 27th Cologne Workshop on Dope Analysis, 1st to 6th March 2009",

note = "Cologne Workshop on Dope Analysis ; Conference date: 01-03-2009 Through 06-03-2009",

}

Renterghem, PV, Eenoo, PV, Geyer, H , Schänzer, W & Delbeke, FT 2009, Alternative steroid profiling : reference ranges for urinary endogenous steroids in a Caucasian population of athletes. in W Schänzer, H Geyer, A Gotzmann & U Mareck (Hrsg.), Recent advances in doping analysis (17) : Proceedings of the Manfred Donike Workshop ; 27th Cologne Workshop on Dope Analysis, 1st to 6th March 2009. Recent advances in doping analysis, Bd. 17, Sportverlag Strauß, S. 81-90, Cologne Workshop on Dope Analysis, Köln, Deutschland, 01.03.09.

Alternative steroid profiling : reference ranges for urinary endogenous steroids in a Caucasian population of athletes. / Renterghem, P. van; Eenoo, P. van; Geyer, Hans et al.
Recent advances in doping analysis (17) : Proceedings of the Manfred Donike Workshop ; 27th Cologne Workshop on Dope Analysis, 1st to 6th March 2009. Hrsg. / Wilhelm Schänzer; Hans Geyer; A. Gotzmann; Ute Mareck. Sportverlag Strauß, 2009. S. 81-90 (Recent advances in doping analysis; Band 17).

Publikation: Beitrag in Buch/Bericht/Konferenzband › Konferenzbeitrag - Aufsatz in Konferenzband › Forschung

TY - CHAP

T1 - Alternative steroid profiling : reference ranges for urinary endogenous steroids in a Caucasian population of athletes

AU - Renterghem, P. van

AU - Eenoo, P. van

AU - Geyer, Hans

AU - Schänzer, Wilhelm

AU - Delbeke, F.T.

N1 - Conference code: 27

PY - 2009

Y1 - 2009

N2 - A comprehensive screening method for steroid profiling was developed covering 29 steroid metabolites. Additionally, 10 steroid ratios were evaluated. Based upon a reference population of more than 3000 samples from healthy athletes the reference values were established at 3 different levels: 97.5%, 99% and 99.9%. Using the extended method and the reference ranges, 2 additional metabolites from 6-oxo-Adion were identified; 6ß-OH-Andro and 6ß-OH-Etio could stretch the detection time for 6-oxo-Adion administration until 36h. In the case of 7-keto-DHEA, 7α-OH-T can be regarded as additional specific metabolite. 7-keto-DHEA can be detected 36h after intake although steroid ratios indicate prolonged changes up to 48h of the steroid profile. Aus dem Text

AB - A comprehensive screening method for steroid profiling was developed covering 29 steroid metabolites. Additionally, 10 steroid ratios were evaluated. Based upon a reference population of more than 3000 samples from healthy athletes the reference values were established at 3 different levels: 97.5%, 99% and 99.9%. Using the extended method and the reference ranges, 2 additional metabolites from 6-oxo-Adion were identified; 6ß-OH-Andro and 6ß-OH-Etio could stretch the detection time for 6-oxo-Adion administration until 36h. In the case of 7-keto-DHEA, 7α-OH-T can be regarded as additional specific metabolite. 7-keto-DHEA can be detected 36h after intake although steroid ratios indicate prolonged changes up to 48h of the steroid profile. Aus dem Text

KW - Biochemie

KW - Doping

KW - Dopinganalyse

KW - Dopingnachweis

KW - Gaschromatographie

KW - Massenspektrometrie

KW - Screening

KW - Sportmedizin

KW - Steroid

KW - Untersuchungsmethode

KW - Urinausscheidung

KW - Urinuntersuchung

M3 - Konferenzbeitrag - Aufsatz in Konferenzband

T3 - Recent advances in doping analysis

SP - 81

EP - 90

BT - Recent advances in doping analysis (17) : Proceedings of the Manfred Donike Workshop ; 27th Cologne Workshop on Dope Analysis, 1st to 6th March 2009

A2 - Schänzer, Wilhelm

A2 - Geyer, Hans

A2 - Gotzmann, A.

A2 - Mareck, Ute

PB - Sportverlag Strauß

T2 - Cologne Workshop on Dope Analysis

Y2 - 1 March 2009 through 6 March 2009

ER -

Renterghem PV, Eenoo PV, Geyer H , Schänzer W, Delbeke FT. Alternative steroid profiling : reference ranges for urinary endogenous steroids in a Caucasian population of athletes. in Schänzer W, Geyer H, Gotzmann A, Mareck U, Hrsg., Recent advances in doping analysis (17) : Proceedings of the Manfred Donike Workshop ; 27th Cologne Workshop on Dope Analysis, 1st to 6th March 2009. Sportverlag Strauß. 2009. S. 81-90. (Recent advances in doping analysis).