TY - JOUR
T1 - Cardiorespiratory Fitness and Cognitive Function are Positively Related Among Participants with Mild and Subjective Cognitive Impairment
AU - Stuckenschneider, Tim
AU - Askew, Christopher David
AU - Rüdiger, Stefanie
AU - Cristina Polidori, Maria
AU - Abeln, Vera
AU - Vogt, Tobias
AU - Krome, Andreas
AU - Olde Rikkert, Marcel
AU - Lawlor, Brian
AU - Schneider, Stefan
AU - NeuroExercise Study Group
PY - 2018/3/27
Y1 - 2018/3/27
N2 - Background: By 2030, about 74
million people will be diagnosed with dementia, and many more will
experience subjective (SCI) or mild cognitive impairment (MCI). As
physical inactivity has been identified to be a strong modifiable risk
factor for dementia, exercise and physical activity (PA) may be important
parameters to predict the progression from MCI to dementia, but might
also represent disease trajectory modifying strategies for SCI and MCI.Objective: A better understanding of the relationship between activity,
fitness, and cognitive function across the spectrum of MCI and SCI would
provide an insight into the potential utility of PA and fitness as
early markers, and treatment targets to prevent cognitive decline.Methods: 121 participants were stratified into three groups, late MCI
(LMCI), early MCI (EMCI), and SCI based on the Montreal Cognitive
Assessment (MoCA). Cognitive function assessments also included the
Trail Making Test A+B, and a verbal fluency test. PA levels were
evaluated with an interviewer-administered questionnaire (LAPAQ) and an
activity monitor. An incremental exercise test was performed to estimate
cardiorespiratory fitness and to determine exercise capacity relative
to population normative data.Results: ANCOVA revealed that LMCI subjects
had the lowest PA levels (LAPAQ, p = 0.018; activity monitor,
p = 0.041), and the lowest exercise capacity in relation to normative
values (p = 0.041). Moreover, a modest correlation between MoCA and
cardiorespiratory fitness (r = 0.25; p < 0.05) was found.Conclusion: These findings suggest that during the earliest stages of
cognitive impairment PA and exercise capacity might present a marker for
the risk of further cognitive decline. This finding warrants further
investigation using longitudinal cohort studies.
AB - Background: By 2030, about 74
million people will be diagnosed with dementia, and many more will
experience subjective (SCI) or mild cognitive impairment (MCI). As
physical inactivity has been identified to be a strong modifiable risk
factor for dementia, exercise and physical activity (PA) may be important
parameters to predict the progression from MCI to dementia, but might
also represent disease trajectory modifying strategies for SCI and MCI.Objective: A better understanding of the relationship between activity,
fitness, and cognitive function across the spectrum of MCI and SCI would
provide an insight into the potential utility of PA and fitness as
early markers, and treatment targets to prevent cognitive decline.Methods: 121 participants were stratified into three groups, late MCI
(LMCI), early MCI (EMCI), and SCI based on the Montreal Cognitive
Assessment (MoCA). Cognitive function assessments also included the
Trail Making Test A+B, and a verbal fluency test. PA levels were
evaluated with an interviewer-administered questionnaire (LAPAQ) and an
activity monitor. An incremental exercise test was performed to estimate
cardiorespiratory fitness and to determine exercise capacity relative
to population normative data.Results: ANCOVA revealed that LMCI subjects
had the lowest PA levels (LAPAQ, p = 0.018; activity monitor,
p = 0.041), and the lowest exercise capacity in relation to normative
values (p = 0.041). Moreover, a modest correlation between MoCA and
cardiorespiratory fitness (r = 0.25; p < 0.05) was found.Conclusion: These findings suggest that during the earliest stages of
cognitive impairment PA and exercise capacity might present a marker for
the risk of further cognitive decline. This finding warrants further
investigation using longitudinal cohort studies.
KW - Cardiorespiratory fitness
KW - mild cognitive impairment
KW - Montreal Cognitive Assessment
KW - physical activity
KW - subjective cognitive impairment
U2 - 10.3233/JAD-170996
DO - 10.3233/JAD-170996
M3 - Journal articles
C2 - 29614659
SN - 1387-2877
VL - 62
SP - 1865
EP - 1875
JO - Journal of Alzheimer's Disease
JF - Journal of Alzheimer's Disease
IS - 4
ER -