Chemotherapie-induzierte Polyneuropathie

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Chemotherapy-induced peripheral neuropathy (CIPN) is a common and relevant side effect of antineoplastic agents such as cisplatin, paclitaxel, vincristine and bortezomib. Over the last years, significant progress has been achieved in elucidating the underlying pathomechanisms of CIPN using both in vivo and in vitro models. These studies suggest that mitochondrial toxicity, disturbed axonal transport, toxic effects on Schwann cells and activation of the immune system contribute to the pathogenesis of CIPN. This review provides an overview of the current pathogenetic concepts of CIPN. In addition, experimental approaches that aim at preventing or ameliorating neurotoxic effects of antineoplastic agents are discussed.

Titel in ÜbersetzungChemotherapy-induced Peripheral Neuropathy
OriginalspracheDeutsch
ZeitschriftFortschritte der Neurologie-Psychiatrie
Jahrgang83
Heft8
Seiten (von - bis)427-436
Seitenumfang10
ISSN0720-4299
DOIs
PublikationsstatusVeröffentlicht - 08.2015

ID: 1552080

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