Abstract
In persons with multiple sclerosis (PwMS), the neutrophil-to-lymphocyte ratio (NLR) is associated with disability status, symptomatology and disease activity. High-intensity interval training (HIIT) improves many symptoms in PwMS and may positively influence disease progression. Here, we present results from a randomized controlled trial during inpatient rehabilitation on immediate (single bout) and training (3-week intervention) effects of HIIT versus moderate continuous training on NLR and related cellular inflammation markers. Only HIIT reduced the NLR over the 3-week intervention period. These training effects might be due to repetitive inflammatory states with compensatory anti-inflammatory counterbalancing after each HIIT session.
Originalsprache | Englisch |
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Zeitschrift | Multiple Sclerosis Journal |
ISSN | 1352-4585 |
DOIs | |
Publikationsstatus | Veröffentlicht - 2020 |
Fachgebiete und Schlagwörter
- HIIT
- Multiple sclerosis
- NLR
- cellular inflammation marker
- exercise
- high-intensity interval exercise
- inflammation
- rehabilitation