Hypoxia-inducible factor (HIF) pathway as target for doping purposes and mass spectrometric characterisation of orally available model HIF-stabilizers

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Aiming at analytical method design, we studied the mass spectrometric dissociation behaviour of 5 isoquinoline-3-carboxamides that might potentially be clinically relevant HIF stabilisers according to literature data and patent specifications. Mass spectrometric information required for the development of analytical assays for HIF stabilisers with isoquinoline scaffold was gained by studying the collision induced dissociation behaviour of the five protonated model HIF-PHI 1 and 4-7. Herein, we exemplary discuss the CID of compound 1 in detail. Aus dem Text
OriginalspracheEnglisch
TitelRecent advances in doping analysis (17) : Proceedings of the Manfred Donike Workshop ; 27th Cologne Workshop on Dope Analysis, 1st to 6th March 2009
Redakteure/-innenWilhelm Schänzer, Hans Geyer, A. Gotzmann, Ute Mareck
Seitenumfang10
Herausgeber/inSportverlag Strauß
Erscheinungsdatum2009
Seiten155-164
PublikationsstatusVeröffentlicht - 2009
VeranstaltungCologne Workshop on Dope Analysis - Köln, Deutschland
Dauer: 01.03.200906.03.2009
Konferenznummer: 27

ID: 189834

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