Localization of the neuropeptide galanin in nerve fibers and epithelial keratinocytes of the rat molar gingiva

Publikationen: Beitrag in FachzeitschriftZeitschriftenaufsätzeForschung

AutorInnen

  • Michael A Baumann
  • Yüksel Korkmaz
  • Wilhelm Bloch
  • Annette Schmidt
  • Klaus Addicks
  • Hannsjörg Schröder

Forschungseinrichtungen

Details

Knowledge of the histochemical substrates of cellular and neurovascular connections in the gingiva is essential in order to understand the initial mechanisms of inflammation in the periodontium. Since the localization of the neuroendocrine peptide galanin in the gingiva is still unclear, we used immunohistochemical, in situ hybridization and immunoblot techniques to assess the localization of galanin in the gingiva of rat molars. Galanin-immunoreactive nerve fibers were located around blood vessels in the lamina propria, beneath the epithelium, in the epithelial-proprial junction and in the basal layer of the epithelium. Galanin was highly expressed in the suprabasal keratinocytes of the gingival epithelium. The localization of galanin in gingival nerve fibers and the expression of galanin in keratinocytes of the gingival epithelium indicate that galanin may be a possible regulator of different cellular functions in the gingiva.

OriginalspracheEnglisch
ZeitschriftEuropean journal of oral sciences
Jahrgang111
Heft2
Seiten (von - bis)175-178
Seitenumfang4
ISSN0909-8836
PublikationsstatusVeröffentlicht - 01.04.2003

ID: 72653

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