RBC NOS: regulatory mechanisms and therapeutic aspects

Burcin Ozüyaman, Marijke Grau, Malte Kelm, Marc W Merx, Petra Kleinbongard

Publikation: Beitrag in FachzeitschriftZeitschriftenaufsätzeForschungBegutachtung

Abstract

Nitric oxide (NO), one of the most important vascular signaling molecules, is primarily produced by endothelial NO synthase (eNOS). eNOS is tightly regulated by its substrate l-arginine, cofactors and diverse interacting proteins. Interestingly, an NO synthase (NOS) was described within red blood cells (RBC NOS), and it was recently shown to significantly contribute to the intravascular NO pool and to regulate physiologically relevant mechanisms. However, the regulatory mechanisms and clinical implications of RBC NOS are unknown. The aim of this review is to highlight intracellular RBC NOS interactions and the role of RBC NOS in RBC homeostasis. Furthermore, macro- and microvascular diseases affected by RBC-derived NO are discussed.

OriginalspracheEnglisch
ZeitschriftTrends in molecular medicine
Jahrgang14
Ausgabenummer7
Seiten (von - bis)314-22
Seitenumfang9
ISSN1471-4914
DOIs
PublikationsstatusVeröffentlicht - 01.07.2008

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