Recovery from 6-month spaceflight at the International Space Station: muscle-related stress into a proinflammatory setting

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Recovery from 6-month spaceflight at the International Space Station : muscle-related stress into a proinflammatory setting. / Capri, Miriam; Morsiani, Cristina; Santoro, Aurelia; Moriggi, Manuela; Conte, Maria; Martucci, Morena; Bellavista, Elena; Fabbri, Cristina; Giampieri, Enrico; Albracht, Kirsten; Flück, Martin; Ruoss, Severin; Brocca, Lorenza; Canepari, Monica; Longa, Emanuela; Di Giulio, Irene; Bottinelli, Roberto; Cerretelli, Paolo; Salvioli, Stefano; Gelfi, Cecilia; Franceschi, Claudio; Narici, Marco; Rittweger, Jörn.

in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Jahrgang 33, Nr. 4, 08.01.2019, S. 5168-5180.

Publikationen: Beitrag in FachzeitschriftZeitschriftenaufsätzeForschungBegutachtung

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Capri, M, Morsiani, C, Santoro, A, Moriggi, M, Conte, M, Martucci, M, Bellavista, E, Fabbri, C, Giampieri, E, Albracht, K, Flück, M, Ruoss, S, Brocca, L, Canepari, M, Longa, E, Di Giulio, I, Bottinelli, R, Cerretelli, P, Salvioli, S, Gelfi, C, Franceschi, C, Narici, M & Rittweger, J 2019, 'Recovery from 6-month spaceflight at the International Space Station: muscle-related stress into a proinflammatory setting' FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Jg. 33, Nr. 4, S. 5168-5180. https://doi.org/10.1096/fj.201801625R

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@article{c28049834fa3475f8606ab2c087807dc,
title = "Recovery from 6-month spaceflight at the International Space Station: muscle-related stress into a proinflammatory setting",
abstract = "The Sarcolab pilot study of 2 crewmembers, investigated before and after a 6-mo International Space Station mission, has demonstrated the substantial muscle wasting and weakness, along with disruption of muscle's oxidative metabolism. The present work aimed at evaluating the pro/anti-inflammatory status in the same 2 crewmembers (A, B). Blood circulating (c-)microRNAs (miRs), c-proteasome, c-mitochondrial DNA, and cytokines were assessed by real-time quantitative PCR or ELISA tests. Time series analysis was performed ( i.e., before flight and after landing) at 1 and 15 d of recovery (R+1 and R+15, respectively). C-biomarkers were compared with an age-matched control population and with two-dimensional proteomic analysis of the 2 crewmembers' muscle biopsies. Striking differences were observed between the 2 crewmembers at R+1, in terms of inflamma-miRs (c-miRs-21-5p, -126-3p, and -146a-5p), muscle specific (myo)-miR-206, c-proteasome, and IL-6/leptin, thus making the 2 astronauts dissimilar to each other. Final recovery levels of c-proteasome, c-inflamma-miRs, and c-myo-miR-206 were not reverted to the baseline values in crewmember A. In both crewmembers, myo-miR-206 changed significantly after recovery. Muscle biopsy of astronaut A showed an impressive 80{\%} increase of α-1-antitrypsin, a target of miR-126-3p. These results point to a strong stress response induced by spaceflight involving muscle tissue and the proinflammatory setting, where inflamma-miRs and myo-miR-206 mediate the systemic recovery phase after landing.-Capri, M., Morsiani, C., Santoro, A., Moriggi, M., Conte, M., Martucci, M., Bellavista, E., Fabbri, C., Giampieri, E., Albracht, K., Fl{\"u}ck, M., Ruoss, S., Brocca, L., Canepari, M., Longa, E., Di Giulio, I., Bottinelli, R., Cerretelli, P., Salvioli, S., Gelfi, C., Franceschi, C., Narici, M., Rittweger, J. Recovery from six-month spaceflight at the International Space Station: muscle-related stress into a proinflammatory setting.",
keywords = "Biomechanik, Physiologie, Biomechanics, muscle, physiology, muskel, sehne, tendon, adaptation, plasticity",
author = "Miriam Capri and Cristina Morsiani and Aurelia Santoro and Manuela Moriggi and Maria Conte and Morena Martucci and Elena Bellavista and Cristina Fabbri and Enrico Giampieri and Kirsten Albracht and Martin Fl{\"u}ck and Severin Ruoss and Lorenza Brocca and Monica Canepari and Emanuela Longa and {Di Giulio}, Irene and Roberto Bottinelli and Paolo Cerretelli and Stefano Salvioli and Cecilia Gelfi and Claudio Franceschi and Marco Narici and J{\"o}rn Rittweger",
year = "2019",
month = "1",
day = "8",
doi = "10.1096/fj.201801625R",
language = "English",
volume = "33",
pages = "5168--5180",
journal = "FASEB journal : official publication of the Federation of American Societies for Experimental Biology",
issn = "1530-6860",
publisher = "FASEB",
number = "4",

}

RIS

TY - JOUR

T1 - Recovery from 6-month spaceflight at the International Space Station

T2 - FASEB journal : official publication of the Federation of American Societies for Experimental Biology

AU - Capri, Miriam

AU - Morsiani, Cristina

AU - Santoro, Aurelia

AU - Moriggi, Manuela

AU - Conte, Maria

AU - Martucci, Morena

AU - Bellavista, Elena

AU - Fabbri, Cristina

AU - Giampieri, Enrico

AU - Albracht, Kirsten

AU - Flück, Martin

AU - Ruoss, Severin

AU - Brocca, Lorenza

AU - Canepari, Monica

AU - Longa, Emanuela

AU - Di Giulio, Irene

AU - Bottinelli, Roberto

AU - Cerretelli, Paolo

AU - Salvioli, Stefano

AU - Gelfi, Cecilia

AU - Franceschi, Claudio

AU - Narici, Marco

AU - Rittweger, Jörn

PY - 2019/1/8

Y1 - 2019/1/8

N2 - The Sarcolab pilot study of 2 crewmembers, investigated before and after a 6-mo International Space Station mission, has demonstrated the substantial muscle wasting and weakness, along with disruption of muscle's oxidative metabolism. The present work aimed at evaluating the pro/anti-inflammatory status in the same 2 crewmembers (A, B). Blood circulating (c-)microRNAs (miRs), c-proteasome, c-mitochondrial DNA, and cytokines were assessed by real-time quantitative PCR or ELISA tests. Time series analysis was performed ( i.e., before flight and after landing) at 1 and 15 d of recovery (R+1 and R+15, respectively). C-biomarkers were compared with an age-matched control population and with two-dimensional proteomic analysis of the 2 crewmembers' muscle biopsies. Striking differences were observed between the 2 crewmembers at R+1, in terms of inflamma-miRs (c-miRs-21-5p, -126-3p, and -146a-5p), muscle specific (myo)-miR-206, c-proteasome, and IL-6/leptin, thus making the 2 astronauts dissimilar to each other. Final recovery levels of c-proteasome, c-inflamma-miRs, and c-myo-miR-206 were not reverted to the baseline values in crewmember A. In both crewmembers, myo-miR-206 changed significantly after recovery. Muscle biopsy of astronaut A showed an impressive 80% increase of α-1-antitrypsin, a target of miR-126-3p. These results point to a strong stress response induced by spaceflight involving muscle tissue and the proinflammatory setting, where inflamma-miRs and myo-miR-206 mediate the systemic recovery phase after landing.-Capri, M., Morsiani, C., Santoro, A., Moriggi, M., Conte, M., Martucci, M., Bellavista, E., Fabbri, C., Giampieri, E., Albracht, K., Flück, M., Ruoss, S., Brocca, L., Canepari, M., Longa, E., Di Giulio, I., Bottinelli, R., Cerretelli, P., Salvioli, S., Gelfi, C., Franceschi, C., Narici, M., Rittweger, J. Recovery from six-month spaceflight at the International Space Station: muscle-related stress into a proinflammatory setting.

AB - The Sarcolab pilot study of 2 crewmembers, investigated before and after a 6-mo International Space Station mission, has demonstrated the substantial muscle wasting and weakness, along with disruption of muscle's oxidative metabolism. The present work aimed at evaluating the pro/anti-inflammatory status in the same 2 crewmembers (A, B). Blood circulating (c-)microRNAs (miRs), c-proteasome, c-mitochondrial DNA, and cytokines were assessed by real-time quantitative PCR or ELISA tests. Time series analysis was performed ( i.e., before flight and after landing) at 1 and 15 d of recovery (R+1 and R+15, respectively). C-biomarkers were compared with an age-matched control population and with two-dimensional proteomic analysis of the 2 crewmembers' muscle biopsies. Striking differences were observed between the 2 crewmembers at R+1, in terms of inflamma-miRs (c-miRs-21-5p, -126-3p, and -146a-5p), muscle specific (myo)-miR-206, c-proteasome, and IL-6/leptin, thus making the 2 astronauts dissimilar to each other. Final recovery levels of c-proteasome, c-inflamma-miRs, and c-myo-miR-206 were not reverted to the baseline values in crewmember A. In both crewmembers, myo-miR-206 changed significantly after recovery. Muscle biopsy of astronaut A showed an impressive 80% increase of α-1-antitrypsin, a target of miR-126-3p. These results point to a strong stress response induced by spaceflight involving muscle tissue and the proinflammatory setting, where inflamma-miRs and myo-miR-206 mediate the systemic recovery phase after landing.-Capri, M., Morsiani, C., Santoro, A., Moriggi, M., Conte, M., Martucci, M., Bellavista, E., Fabbri, C., Giampieri, E., Albracht, K., Flück, M., Ruoss, S., Brocca, L., Canepari, M., Longa, E., Di Giulio, I., Bottinelli, R., Cerretelli, P., Salvioli, S., Gelfi, C., Franceschi, C., Narici, M., Rittweger, J. Recovery from six-month spaceflight at the International Space Station: muscle-related stress into a proinflammatory setting.

KW - Biomechanik

KW - Physiologie

KW - Biomechanics

KW - muscle

KW - physiology

KW - muskel

KW - sehne

KW - tendon

KW - adaptation

KW - plasticity

U2 - 10.1096/fj.201801625R

DO - 10.1096/fj.201801625R

M3 - Journal articles

VL - 33

SP - 5168

EP - 5180

JO - FASEB journal : official publication of the Federation of American Societies for Experimental Biology

JF - FASEB journal : official publication of the Federation of American Societies for Experimental Biology

SN - 1530-6860

SN - 0892-6638

IS - 4

ER -

ID: 3565490