Safety, hemodynamic effects and detection of acute xenon inhalation: Rationale for banning xenon from sport

Publikationen: Beitrag in FachzeitschriftZeitschriftenaufsätzeForschungBegutachtung

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Safety, hemodynamic effects and detection of acute xenon inhalation : Rationale for banning xenon from sport. / Lawley, Justin Stevan; Gatterer, Hannes; Dias, Katrin A; Howden, Erin J; Sarma, Satyam; Cornwell, William K; Hearon, Christopher M; Samels, Mitchel; Everding, Braden; Hendrix, Max; Piper, Thomas; Thevis, Mario; Levine, Benjamin D.

in: Journal of applied physiology (Bethesda, Md. : 1985), Jahrgang 127, Nr. 6, 01.12.2019, S. 1511-1518.

Publikationen: Beitrag in FachzeitschriftZeitschriftenaufsätzeForschungBegutachtung

Harvard

Lawley, JS, Gatterer, H, Dias, KA, Howden, EJ, Sarma, S, Cornwell, WK, Hearon, CM, Samels, M, Everding, B, Hendrix, M, Piper, T, Thevis, M & Levine, BD 2019, 'Safety, hemodynamic effects and detection of acute xenon inhalation: Rationale for banning xenon from sport', Journal of applied physiology (Bethesda, Md. : 1985), Jg. 127, Nr. 6, S. 1511-1518. https://doi.org/10.1152/japplphysiol.00290.2019

APA

Lawley, J. S., Gatterer, H., Dias, K. A., Howden, E. J., Sarma, S., Cornwell, W. K., Hearon, C. M., Samels, M., Everding, B., Hendrix, M., Piper, T., Thevis, M., & Levine, B. D. (2019). Safety, hemodynamic effects and detection of acute xenon inhalation: Rationale for banning xenon from sport. Journal of applied physiology (Bethesda, Md. : 1985), 127(6), 1511-1518. https://doi.org/10.1152/japplphysiol.00290.2019

Vancouver

Bibtex

@article{54caac61a0e74f2fb27ab60a33c0b743,
title = "Safety, hemodynamic effects and detection of acute xenon inhalation: Rationale for banning xenon from sport",
abstract = "This study aimed to quantify the sedative effects, detection rates, and cardiovascular responses to xenon. On 3 occasions, participants breathed xenon (FiXe 30% for 20 min; FiXe 50% for 5 min; FiXe 70% for 2 min) in a nonblinded design. Sedation was monitored by a board-certified anesthesiologist. During 70% xenon, participants were also verbally instructed to operate a manual value with time-to-task failure being recorded. Beat-by-beat hemodynamics were measured continuously by ECG, photoplethysmography, and transcranial Doppler. Over 48 h postadministration, xenon was measured in blood and urine by gas chromatography-mass spectrometry. Xenon caused variable levels of sedation and restlessness. Task failure of the selfoperating value occurred at 60-90 s in most individuals. Over the first minute, 50% and 70% xenon caused a substantial reduction in total peripheral resistance (P <0.05). All dosages caused an increase in cardiac output (P <0.05). By the end of xenon inhalation, slight hypertension was observed after all three doses (P <0.05), with an increase in middle cerebral artery velocity (P <0.05). Xenon was consistently detected, albeit in trace amounts, up to 3 h after all three doses of xenon inhalation in blood and urine with variable results thereafter. Xenon inhalation caused sedation incompatible with selfoperation of a breathing apparatus, thus causing a potential lifethreatening condition in the absence of an anesthesiologist. Yet, xenon can only be reliably detected in blood and urine up to 3 h postacute dosing. NEW & NOTEWORTHY Breathing xenon in dosages conceivable for doping purposes (FiXe 30% for 20 min; FiXe 50% for 5 min; FiXe 70% for 2 min) causes an initial rapid fall in total peripheral resistance with tachycardia and thereafter a mild hypertension with elevated middle cerebral artery velocity. These dose duration intervals cause sedation that is incompatible with operating a breathing apparatus and can only be detected in blood and urine samples with a high probability for up to ~3 h.",
keywords = "Anesthesia, Blood pressure, Brain blood flow, Doping",
author = "Lawley, {Justin Stevan} and Hannes Gatterer and Dias, {Katrin A} and Howden, {Erin J} and Satyam Sarma and Cornwell, {William K} and Hearon, {Christopher M} and Mitchel Samels and Braden Everding and Max Hendrix and Thomas Piper and Mario Thevis and Levine, {Benjamin D}",
note = "Online: 15.08.2019",
year = "2019",
month = dec,
day = "1",
doi = "10.1152/japplphysiol.00290.2019",
language = "English",
volume = "127",
pages = "1511--1518",
journal = "Journal of applied physiology (Bethesda, Md. : 1985)",
issn = "8750-7587",
publisher = "American Physiological Society",
number = "6",

}

RIS

TY - JOUR

T1 - Safety, hemodynamic effects and detection of acute xenon inhalation

T2 - Rationale for banning xenon from sport

AU - Lawley, Justin Stevan

AU - Gatterer, Hannes

AU - Dias, Katrin A

AU - Howden, Erin J

AU - Sarma, Satyam

AU - Cornwell, William K

AU - Hearon, Christopher M

AU - Samels, Mitchel

AU - Everding, Braden

AU - Hendrix, Max

AU - Piper, Thomas

AU - Thevis, Mario

AU - Levine, Benjamin D

N1 - Online: 15.08.2019

PY - 2019/12/1

Y1 - 2019/12/1

N2 - This study aimed to quantify the sedative effects, detection rates, and cardiovascular responses to xenon. On 3 occasions, participants breathed xenon (FiXe 30% for 20 min; FiXe 50% for 5 min; FiXe 70% for 2 min) in a nonblinded design. Sedation was monitored by a board-certified anesthesiologist. During 70% xenon, participants were also verbally instructed to operate a manual value with time-to-task failure being recorded. Beat-by-beat hemodynamics were measured continuously by ECG, photoplethysmography, and transcranial Doppler. Over 48 h postadministration, xenon was measured in blood and urine by gas chromatography-mass spectrometry. Xenon caused variable levels of sedation and restlessness. Task failure of the selfoperating value occurred at 60-90 s in most individuals. Over the first minute, 50% and 70% xenon caused a substantial reduction in total peripheral resistance (P <0.05). All dosages caused an increase in cardiac output (P <0.05). By the end of xenon inhalation, slight hypertension was observed after all three doses (P <0.05), with an increase in middle cerebral artery velocity (P <0.05). Xenon was consistently detected, albeit in trace amounts, up to 3 h after all three doses of xenon inhalation in blood and urine with variable results thereafter. Xenon inhalation caused sedation incompatible with selfoperation of a breathing apparatus, thus causing a potential lifethreatening condition in the absence of an anesthesiologist. Yet, xenon can only be reliably detected in blood and urine up to 3 h postacute dosing. NEW & NOTEWORTHY Breathing xenon in dosages conceivable for doping purposes (FiXe 30% for 20 min; FiXe 50% for 5 min; FiXe 70% for 2 min) causes an initial rapid fall in total peripheral resistance with tachycardia and thereafter a mild hypertension with elevated middle cerebral artery velocity. These dose duration intervals cause sedation that is incompatible with operating a breathing apparatus and can only be detected in blood and urine samples with a high probability for up to ~3 h.

AB - This study aimed to quantify the sedative effects, detection rates, and cardiovascular responses to xenon. On 3 occasions, participants breathed xenon (FiXe 30% for 20 min; FiXe 50% for 5 min; FiXe 70% for 2 min) in a nonblinded design. Sedation was monitored by a board-certified anesthesiologist. During 70% xenon, participants were also verbally instructed to operate a manual value with time-to-task failure being recorded. Beat-by-beat hemodynamics were measured continuously by ECG, photoplethysmography, and transcranial Doppler. Over 48 h postadministration, xenon was measured in blood and urine by gas chromatography-mass spectrometry. Xenon caused variable levels of sedation and restlessness. Task failure of the selfoperating value occurred at 60-90 s in most individuals. Over the first minute, 50% and 70% xenon caused a substantial reduction in total peripheral resistance (P <0.05). All dosages caused an increase in cardiac output (P <0.05). By the end of xenon inhalation, slight hypertension was observed after all three doses (P <0.05), with an increase in middle cerebral artery velocity (P <0.05). Xenon was consistently detected, albeit in trace amounts, up to 3 h after all three doses of xenon inhalation in blood and urine with variable results thereafter. Xenon inhalation caused sedation incompatible with selfoperation of a breathing apparatus, thus causing a potential lifethreatening condition in the absence of an anesthesiologist. Yet, xenon can only be reliably detected in blood and urine up to 3 h postacute dosing. NEW & NOTEWORTHY Breathing xenon in dosages conceivable for doping purposes (FiXe 30% for 20 min; FiXe 50% for 5 min; FiXe 70% for 2 min) causes an initial rapid fall in total peripheral resistance with tachycardia and thereafter a mild hypertension with elevated middle cerebral artery velocity. These dose duration intervals cause sedation that is incompatible with operating a breathing apparatus and can only be detected in blood and urine samples with a high probability for up to ~3 h.

KW - Anesthesia

KW - Blood pressure

KW - Brain blood flow

KW - Doping

UR - https://www.mendeley.com/catalogue/244b9617-af9c-3807-9843-cf887e608c51/

U2 - 10.1152/japplphysiol.00290.2019

DO - 10.1152/japplphysiol.00290.2019

M3 - Journal articles

C2 - 31414955

VL - 127

SP - 1511

EP - 1518

JO - Journal of applied physiology (Bethesda, Md. : 1985)

JF - Journal of applied physiology (Bethesda, Md. : 1985)

SN - 8750-7587

IS - 6

ER -

ID: 4609584