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**Temporal dissociation between muscle and pulmonary oxygen uptake kinetics : influences of perfusion dynamics and arteriovenous oxygen concentration differences in muscles and lungs.** / Drescher, U; Koschate, J; Thieschäfer, L; Schneider, S; Hoffmann, U.

Publikationen: Beitrag in Fachzeitschrift › Zeitschriftenaufsätze › Forschung › Begutachtung

Drescher, U, Koschate, J, Thieschäfer, L, Schneider, S & Hoffmann, U 2018, 'Temporal dissociation between muscle and pulmonary oxygen uptake kinetics: influences of perfusion dynamics and arteriovenous oxygen concentration differences in muscles and lungs', *European journal of applied physiology*, Jg. 118, Nr. 9, S. 1845-1856. https://doi.org/10.1007/s00421-018-3916-x

Drescher, U., Koschate, J., Thieschäfer, L., Schneider, S., & Hoffmann, U. (2018). Temporal dissociation between muscle and pulmonary oxygen uptake kinetics: influences of perfusion dynamics and arteriovenous oxygen concentration differences in muscles and lungs. *European journal of applied physiology*, *118*(9), 1845-1856. https://doi.org/10.1007/s00421-018-3916-x

Drescher U, Koschate J, Thieschäfer L, Schneider S, Hoffmann U. Temporal dissociation between muscle and pulmonary oxygen uptake kinetics: influences of perfusion dynamics and arteriovenous oxygen concentration differences in muscles and lungs. European journal of applied physiology. 2018 Jun 22;118(9):1845-1856. https://doi.org/10.1007/s00421-018-3916-x

@article{aac78ee0fcb84081b5a8630e8fabaec3,

title = "Temporal dissociation between muscle and pulmonary oxygen uptake kinetics: influences of perfusion dynamics and arteriovenous oxygen concentration differences in muscles and lungs",

abstract = "PURPOSE: The aim of the study was to test whether or not the arteriovenous oxygen concentration difference (avDO2) kinetics at the pulmonary (avDO2pulm) and muscle (avDO2musc) levels is significantly different during dynamic exercise.METHODS: A re-analysis involving six publications dealing with kinetic analysis was utilized with an overall sample size of 69 participants. All studies comprised an identical pseudorandom binary sequence work rate (WR) protocol-WR changes between 30 and 80 W-to analyze the kinetic responses of pulmonary ([Formula: see text]) and muscle ([Formula: see text]) oxygen uptake kinetics as well as those of avDO2pulm and avDO2musc.RESULTS: A significant difference between [Formula: see text] (0.395 ± 0.079) and [Formula: see text] kinetics (0.330 ± 0.078) was observed (p < 0.001), where the variables showed a significant relationship (rSP = 0.744, p < 0.001). There were no significant differences between avDO2musc (0.446 ± 0.077) and avDO2pulm kinetics (0.451 ± 0.075), which are highly correlated (r = 0.929, p < 0.001).CONCLUSION: It is suggested that neither avDO2pulm nor avDO2musc kinetic responses seem to be responsible for the differences between estimated [Formula: see text] and measured [Formula: see text] kinetics. Obviously, the conflation of avDO2 and perfusion ([Formula: see text] ) at different points in time and at different physiological levels drive potential differences in [Formula: see text] and [Formula: see text] kinetics. Therefore, [Formula: see text] should, in general, be considered whenever oxygen uptake kinetics are analyzed or discussed.",

keywords = "Journal Article",

author = "U Drescher and J Koschate and L Thiesch{\"a}fer and S Schneider and U Hoffmann",

year = "2018",

month = jun,

day = "22",

doi = "10.1007/s00421-018-3916-x",

language = "English",

volume = "118",

pages = "1845--1856",

journal = "European journal of applied physiology",

issn = "1439-6319",

publisher = "Springer Verlag",

number = "9",

}

TY - JOUR

T1 - Temporal dissociation between muscle and pulmonary oxygen uptake kinetics

T2 - influences of perfusion dynamics and arteriovenous oxygen concentration differences in muscles and lungs

AU - Drescher, U

AU - Koschate, J

AU - Thieschäfer, L

AU - Schneider, S

AU - Hoffmann, U

PY - 2018/6/22

Y1 - 2018/6/22

N2 - PURPOSE: The aim of the study was to test whether or not the arteriovenous oxygen concentration difference (avDO2) kinetics at the pulmonary (avDO2pulm) and muscle (avDO2musc) levels is significantly different during dynamic exercise.METHODS: A re-analysis involving six publications dealing with kinetic analysis was utilized with an overall sample size of 69 participants. All studies comprised an identical pseudorandom binary sequence work rate (WR) protocol-WR changes between 30 and 80 W-to analyze the kinetic responses of pulmonary ([Formula: see text]) and muscle ([Formula: see text]) oxygen uptake kinetics as well as those of avDO2pulm and avDO2musc.RESULTS: A significant difference between [Formula: see text] (0.395 ± 0.079) and [Formula: see text] kinetics (0.330 ± 0.078) was observed (p < 0.001), where the variables showed a significant relationship (rSP = 0.744, p < 0.001). There were no significant differences between avDO2musc (0.446 ± 0.077) and avDO2pulm kinetics (0.451 ± 0.075), which are highly correlated (r = 0.929, p < 0.001).CONCLUSION: It is suggested that neither avDO2pulm nor avDO2musc kinetic responses seem to be responsible for the differences between estimated [Formula: see text] and measured [Formula: see text] kinetics. Obviously, the conflation of avDO2 and perfusion ([Formula: see text] ) at different points in time and at different physiological levels drive potential differences in [Formula: see text] and [Formula: see text] kinetics. Therefore, [Formula: see text] should, in general, be considered whenever oxygen uptake kinetics are analyzed or discussed.

AB - PURPOSE: The aim of the study was to test whether or not the arteriovenous oxygen concentration difference (avDO2) kinetics at the pulmonary (avDO2pulm) and muscle (avDO2musc) levels is significantly different during dynamic exercise.METHODS: A re-analysis involving six publications dealing with kinetic analysis was utilized with an overall sample size of 69 participants. All studies comprised an identical pseudorandom binary sequence work rate (WR) protocol-WR changes between 30 and 80 W-to analyze the kinetic responses of pulmonary ([Formula: see text]) and muscle ([Formula: see text]) oxygen uptake kinetics as well as those of avDO2pulm and avDO2musc.RESULTS: A significant difference between [Formula: see text] (0.395 ± 0.079) and [Formula: see text] kinetics (0.330 ± 0.078) was observed (p < 0.001), where the variables showed a significant relationship (rSP = 0.744, p < 0.001). There were no significant differences between avDO2musc (0.446 ± 0.077) and avDO2pulm kinetics (0.451 ± 0.075), which are highly correlated (r = 0.929, p < 0.001).CONCLUSION: It is suggested that neither avDO2pulm nor avDO2musc kinetic responses seem to be responsible for the differences between estimated [Formula: see text] and measured [Formula: see text] kinetics. Obviously, the conflation of avDO2 and perfusion ([Formula: see text] ) at different points in time and at different physiological levels drive potential differences in [Formula: see text] and [Formula: see text] kinetics. Therefore, [Formula: see text] should, in general, be considered whenever oxygen uptake kinetics are analyzed or discussed.

KW - Journal Article

U2 - 10.1007/s00421-018-3916-x

DO - 10.1007/s00421-018-3916-x

M3 - Journal articles

C2 - 29934765

VL - 118

SP - 1845

EP - 1856

JO - European journal of applied physiology

JF - European journal of applied physiology

SN - 1439-6319

IS - 9

ER -

ID: 3437966