Abstract
To develop a method for the detection of the misuse of testosterone gel (T-gel) 18 healthy male volunteers were treated for six weeks continuously and intermittently with T-gel (100 mg testosterone per day). Blood and urine samples were collected before, during and after the application of T-gel. The following results were obtained. The treatment with T-gel leads to an increase of serum testosterone and a decrease of LH. The most discriminating parameters of the steroid profile are the ratios testosterone/epitestosterone, 5α-androstane-3 α,17ß-diol / epitestosterone and androsterone/epitestosterone. Individual reference ranges of the parameters are more suitable for the detection of the misuse of T-gel than population based reference ranges. For the GC/C/IRMS analysis suitable target compounds are testosterone and 5α -androstane-3 α,17ß-diol. Verf.-Referat
Originalsprache | Englisch |
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Titel | Recent advances in doping analysis (15) : Proceedings of the Manfred Donike Workshop ; 25th Cologne Workshop on Dope Analysis 25th February to 2nd March 2007 |
Herausgeber*innen | Wilhelm Schänzer, Hans Geyer, A. Gotzmann, Ute Mareck |
Seitenumfang | 10 |
Herausgeber (Verlag) | Sportverlag Strauß |
Erscheinungsdatum | 2007 |
Seiten | 133-142 |
Publikationsstatus | Veröffentlicht - 2007 |
Veranstaltung | Cologne Workshop on Dope Analysis - Köln, Deutschland Dauer: 25.02.2007 → 02.03.2007 Konferenznummer: 25 |
Fachgebiete und Schlagwörter
- Biochemie
- Blut
- Blutuntersuchung
- Doping
- Dopingnachweis
- Epitestosteron
- Gaschromatographie
- Massenspektrometrie
- Messverfahren
- Sportmedizin
- Testosteron
- Untersuchungsmethode
- Urin
- Urinuntersuchung