Unambiguous identification and characterization of a long-term human metabolite of dehydrochloromethyltestosterone

Publikationen: Beitrag in FachzeitschriftZeitschriftenaufsätzeForschungBegutachtung

AutorInnen

  • Guro Forsdahl
  • Thomas Geisendorfer
  • Lorenz Göschl
  • Sandra Pfeffer
  • Peter Gärtner
  • Mario Thevis
  • Günter Gmeiner

Forschungseinrichtungen

Details

In doping control analysis, the characterization of urinary steroid metabolites is of high interest for a targeted and long-term detection of prohibited anabolic androgenic steroids (AAS). In this work, the structure of a long-term metabolite of dehydrochloromethyltestosterone (DHCMT) was elucidated. Altogether, eight possible metabolites with a 17α-methyl-17β-hydroxymethyl - structure were synthesized and compared to a major DHCMT long-term metabolite detected in reference urine excretion samples. The confirmed structure of the metabolite was 4α-chloro-18-nor-17β-hydroxymethyl-17α-methyl-5α-androst-13-en-3α-ol.

OriginalspracheEnglisch
ZeitschriftDrug testing and analysis
Jahrgang10
Heft8
Seiten (von - bis)1244-1250
Seitenumfang7
ISSN1942-7603
DOIs
PublikationsstatusVeröffentlicht - 23.03.2018

ID: 3286112

DOI

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