Zur Funktion des beta3-Adrenozeptors am Herzen: Signaltransduktion, inotroper Effekt und therapeutischer Ausblick

Christian Pott, Dirk Steinritz, Andreas Napp, Wilhelm Bloch, Robert H G Schwinger, Klara Brixius

Publikation: Beitrag in FachzeitschriftZeitschriftenaufsätzeForschung

Abstract

Beta-adrenergic stimulation is an important regulatory mechanism of cardiac function. Next to beta1- and beta2-adrenoceptors, the expression of a third beta-adrenoceptor population, the beta3-adrenoceptor, has recently been evidenced in the human heart. Stimulation of cardiac beta3-adrenoceptors leads to a decrease in contractility via a release of nitric oxide (NO). In this context, different molecular mechanisms of endothelial nitric oxide synthase (eNOS) activation have been uncovered to occur as a consequence of beta3-adrenergic stimulation. In both nonfailing and failing myocardium, beta3-adrenergic stimulation may have a protective effect against excessive chatecolaminergic stimulation as it occurs during somatic and mental stress and during heart failure. For this reason, the beta3-adrenoceptor is discussed as a possible target for the pharmacological therapy of heart failure.

Titel in ÜbersetzungOn the function of beta3-adrenoceptors in the human heart: signal transduction, inotropic effect and therapeutic prospects
OriginalspracheDeutsch
ZeitschriftWiener medizinische Wochenschrift (1946)
Jahrgang156
Ausgabenummer15-16
Seiten (von - bis)451-458
Seitenumfang8
ISSN0043-5341
DOIs
PublikationsstatusVeröffentlicht - 01.08.2006

Fachgebiete und Schlagwörter

  • Adrenergic beta-3 Receptor Agonists
  • Adrenergic beta-Agonists
  • Catecholamines
  • Endothelium, Vascular
  • Enzyme Activation
  • Ethanolamines
  • Heart
  • Heart Failure
  • Humans
  • Myocardial Contraction
  • Nitric Oxide
  • Nitric Oxide Synthase
  • Receptors, Adrenergic, beta-3
  • Signal Transduction
  • Stress, Psychological

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