Estimation of the Metabolic Fluxes of Androgens in peripheral and hepatic Metabolism by 13C/12C-Analysis at natural abundance

Project: Funded by Internal Resources

Research Objective

To estimate the physiologically normal metabolic fluxes of androgenic steroid hormones in peripheral tissues and in the liver. These fluxes are modulated by physiological effects (e.g. physical activity) but also by illicit administration of synthetic androgenic steroids, normally testosterone. Depending on the route of administration (transdermal or oral), testosterone doping should be detectable by abnormally high rates of either peripheral or hepatic androgen fluxes.

Method

Compound specific stable carbon isotope analysis of urinary androgen metabolites. Employment of steady state models of isotopic mass balance.
StatusNot started

ID: 3233852

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