ACE and angiotensinogen gene genotypes and left ventricular mass in athletes

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ACE and angiotensinogen gene genotypes and left ventricular mass in athletes. / Diet, F; Graf, Christine; Mahnke, N; Wassmer, G; Predel, Hans-Georg; Palma-Hohmann, I; Rost, R; Böhm, Michael.

In: European journal of clinical investigation, Vol. 31, No. 10, 01.10.2001, p. 836-842.

Research output: Contribution to journalJournal articlesResearchpeer-review

Harvard

Diet, F, Graf, C, Mahnke, N, Wassmer, G, Predel, H-G, Palma-Hohmann, I, Rost, R & Böhm, M 2001, 'ACE and angiotensinogen gene genotypes and left ventricular mass in athletes', European journal of clinical investigation, vol. 31, no. 10, pp. 836-842.

APA

Diet, F., Graf, C., Mahnke, N., Wassmer, G., Predel, H-G., Palma-Hohmann, I., ... Böhm, M. (2001). ACE and angiotensinogen gene genotypes and left ventricular mass in athletes. European journal of clinical investigation, 31(10), 836-842.

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Bibtex

@article{b402ce4b115d457fbb9a8ecb06fdb38a,
title = "ACE and angiotensinogen gene genotypes and left ventricular mass in athletes",
abstract = "BACKGROUND: Genetic factors may be important in modifying heart size due to long-term athletic training. The significance of polymorphisms of genes of the renin-angiotensin system in myocardial mass in a population of athletes participating in different disciplines is not known.METHODS: The angiotensin I-converting enzyme gene insertion/deletion (I/D) polymorphism, angiotensinogen gene M235T polymorphism and angiotensin II type 1 receptor gene A1166C polymorphism were determined in 83 male Caucasian endurance athletes and associated with left ventricular mass.RESULTS: No association with left ventricular mass was found for the polymorphisms of angiotensin I-converting enzyme gene I/D, angiotensinogen gene M235T and angiotensin II type 1 gene A1166C when studied separately. However, combined analysis of the angiotensin I-converting enzyme gene I/D polymorphism and angiotensinogen gene M235T polymorphism genotypes suggested an association with left ventricular mass (g m(-2)) (P = 0.023). Athletes with the angiotensin I-converting enzyme gene DD/angiotensinogen gene TT genotype combination had greater left ventricular mass compared with all other genotype combinations (179.8 +/- 26.1 g m(-2) vs. 145.2 +/- 27.3 g m(-2), P = 0.003).CONCLUSIONS: These results suggest an association of combined angiotensin I-converting enzyme gene I/D polymorphism genotypes, and angiotensinogen gene M235T polymorphism genotypes with left ventricular hypertrophy due to long-term athletic training. A synergistic effect of angiotensin I-converting enzyme gene DD genotype and angiotensinogen gene TT genotype on left ventricular mass in endurance athletes appears to occur.",
keywords = "Adolescent, Adult, Angiotensinogen, Echocardiography, Genotype, Heart, Heart Ventricles, Humans, Hypertrophy, Left Ventricular, Male, Peptidyl-Dipeptidase A, Physical Endurance, Polymorphism, Genetic, Receptor, Angiotensin, Type 1, Receptors, Angiotensin, Renin-Angiotensin System, Sports",
author = "F Diet and Christine Graf and N Mahnke and G Wassmer and Hans-Georg Predel and I Palma-Hohmann and R Rost and Michael B{\"o}hm",
year = "2001",
month = "10",
day = "1",
language = "English",
volume = "31",
pages = "836--842",
journal = "European journal of clinical investigation",
issn = "0014-2972",
publisher = "Wiley-Blackwell",
number = "10",

}

RIS

TY - JOUR

T1 - ACE and angiotensinogen gene genotypes and left ventricular mass in athletes

AU - Diet, F

AU - Graf, Christine

AU - Mahnke, N

AU - Wassmer, G

AU - Predel, Hans-Georg

AU - Palma-Hohmann, I

AU - Rost, R

AU - Böhm, Michael

PY - 2001/10/1

Y1 - 2001/10/1

N2 - BACKGROUND: Genetic factors may be important in modifying heart size due to long-term athletic training. The significance of polymorphisms of genes of the renin-angiotensin system in myocardial mass in a population of athletes participating in different disciplines is not known.METHODS: The angiotensin I-converting enzyme gene insertion/deletion (I/D) polymorphism, angiotensinogen gene M235T polymorphism and angiotensin II type 1 receptor gene A1166C polymorphism were determined in 83 male Caucasian endurance athletes and associated with left ventricular mass.RESULTS: No association with left ventricular mass was found for the polymorphisms of angiotensin I-converting enzyme gene I/D, angiotensinogen gene M235T and angiotensin II type 1 gene A1166C when studied separately. However, combined analysis of the angiotensin I-converting enzyme gene I/D polymorphism and angiotensinogen gene M235T polymorphism genotypes suggested an association with left ventricular mass (g m(-2)) (P = 0.023). Athletes with the angiotensin I-converting enzyme gene DD/angiotensinogen gene TT genotype combination had greater left ventricular mass compared with all other genotype combinations (179.8 +/- 26.1 g m(-2) vs. 145.2 +/- 27.3 g m(-2), P = 0.003).CONCLUSIONS: These results suggest an association of combined angiotensin I-converting enzyme gene I/D polymorphism genotypes, and angiotensinogen gene M235T polymorphism genotypes with left ventricular hypertrophy due to long-term athletic training. A synergistic effect of angiotensin I-converting enzyme gene DD genotype and angiotensinogen gene TT genotype on left ventricular mass in endurance athletes appears to occur.

AB - BACKGROUND: Genetic factors may be important in modifying heart size due to long-term athletic training. The significance of polymorphisms of genes of the renin-angiotensin system in myocardial mass in a population of athletes participating in different disciplines is not known.METHODS: The angiotensin I-converting enzyme gene insertion/deletion (I/D) polymorphism, angiotensinogen gene M235T polymorphism and angiotensin II type 1 receptor gene A1166C polymorphism were determined in 83 male Caucasian endurance athletes and associated with left ventricular mass.RESULTS: No association with left ventricular mass was found for the polymorphisms of angiotensin I-converting enzyme gene I/D, angiotensinogen gene M235T and angiotensin II type 1 gene A1166C when studied separately. However, combined analysis of the angiotensin I-converting enzyme gene I/D polymorphism and angiotensinogen gene M235T polymorphism genotypes suggested an association with left ventricular mass (g m(-2)) (P = 0.023). Athletes with the angiotensin I-converting enzyme gene DD/angiotensinogen gene TT genotype combination had greater left ventricular mass compared with all other genotype combinations (179.8 +/- 26.1 g m(-2) vs. 145.2 +/- 27.3 g m(-2), P = 0.003).CONCLUSIONS: These results suggest an association of combined angiotensin I-converting enzyme gene I/D polymorphism genotypes, and angiotensinogen gene M235T polymorphism genotypes with left ventricular hypertrophy due to long-term athletic training. A synergistic effect of angiotensin I-converting enzyme gene DD genotype and angiotensinogen gene TT genotype on left ventricular mass in endurance athletes appears to occur.

KW - Adolescent

KW - Adult

KW - Angiotensinogen

KW - Echocardiography

KW - Genotype

KW - Heart

KW - Heart Ventricles

KW - Humans

KW - Hypertrophy, Left Ventricular

KW - Male

KW - Peptidyl-Dipeptidase A

KW - Physical Endurance

KW - Polymorphism, Genetic

KW - Receptor, Angiotensin, Type 1

KW - Receptors, Angiotensin

KW - Renin-Angiotensin System

KW - Sports

M3 - Journal articles

VL - 31

SP - 836

EP - 842

JO - European journal of clinical investigation

JF - European journal of clinical investigation

SN - 0014-2972

IS - 10

ER -

ID: 154533