Acute effects of Paroxetin administration on parameters of neuromuscular fatigue

Research output: Chapter in Book/Report/Conference proceedingConference contribution - Published abstract for conference with selection processResearchpeer-review


Research units


The serotonergic system is known to modulate central fatigue manifestations. Paroxetin (SSRI) is known to inhibit serotonin release, deteriorate presynaptic neurotransmission and explains reduced exercise capacity. SSRI affects endurance type exercises in terms of prolonged time to exhaustion and task failure and impacts cognitive skills.
In a neuromuscular context central and peripheral fatigue effects are differentiated by comparing stimulated and voluntary muscle activations. No study since now has ever looked for coherences between neuromuscular fatigue effects and the contribution of the serotonergic system.
The purpose of the presented study was to identify the role of the serotonergic system within a neuromuscular fatigue protocol which involved a pre – post maximum contraction approach.
i.) the protocol caused distinct central and peripheral neuromuscular fatigue effects
ii.) paroxetine administration had no significant effect on any of the fatigue parameters
Paroxetine is known to firstly inhibit serotonin release after activation of somatodentritic 5-HT1A autoreceptors, thus deteriorating the presynaptic neurotransmission. However these findings of Weicker et al. 2000 were not evident in our results. They rather support the findings of Meussen et al. 2001 who did not find an interference of SSRI with performance. The analysis of data on chronic SSRI administration will probably yield neuromuscular effects which can be attributed to augmented serotonin availability.
Weicker, H., & Strüder, H. (2001). Amino Acids.
Meeusen, R., et al. (2000) Int J Sports Med.

Original languageEnglish
Title of host publication19th Annual Congress of the European College of Sport Science in Amsterdam 2014 : Book of Abstracts
EditorsA. DeHaan
Number of pages1
PublisherTaylor and Francis
Publication date2014
Publication statusPublished - 2014
EventAnnual Congress of the European Colleg of Sport Science - Amsterdam, Netherlands
Duration: 02.07.201405.07.2014
Conference number: 19

ID: 209810


View graph of relations