Acute effects of Paroxetin administration on parameters of neuromuscular fatigue

Research output: Chapter in Book/Report/Conference proceedingConference contribution - Published abstract for conference with selection processResearchpeer-review

Standard

Acute effects of Paroxetin administration on parameters of neuromuscular fatigue. / Knicker, Axel; Buschermöhle, Sarah; Schiffer, Thorsten; Fricke, Hannes; Strüder, Heiko Klaus.

19th Annual Congress of the European College of Sport Science in Amsterdam 2014: Book of Abstracts. ed. / A. DeHaan. Taylor and Francis, 2014.

Research output: Chapter in Book/Report/Conference proceedingConference contribution - Published abstract for conference with selection processResearchpeer-review

Harvard

Knicker, A, Buschermöhle, S, Schiffer, T, Fricke, H & Strüder, HK 2014, Acute effects of Paroxetin administration on parameters of neuromuscular fatigue. in A DeHaan (ed.), 19th Annual Congress of the European College of Sport Science in Amsterdam 2014: Book of Abstracts. Taylor and Francis, Annual Congress of the European Colleg of Sport Science, Amsterdam, Netherlands, 02.07.14.

APA

Knicker, A., Buschermöhle, S., Schiffer, T., Fricke, H., & Strüder, H. K. (2014). Acute effects of Paroxetin administration on parameters of neuromuscular fatigue. In A. DeHaan (Ed.), 19th Annual Congress of the European College of Sport Science in Amsterdam 2014: Book of Abstracts Taylor and Francis.

Vancouver

Knicker A, Buschermöhle S, Schiffer T, Fricke H, Strüder HK. Acute effects of Paroxetin administration on parameters of neuromuscular fatigue. In DeHaan A, editor, 19th Annual Congress of the European College of Sport Science in Amsterdam 2014: Book of Abstracts. Taylor and Francis. 2014

Bibtex

@inbook{8d2b489120b341d68a9bf9eed4837e9f,
title = "Acute effects of Paroxetin administration on parameters of neuromuscular fatigue",
abstract = "The serotonergic system is known to modulate central fatigue manifestations. Paroxetin (SSRI) is known to inhibit serotonin release, deteriorate presynaptic neurotransmission and explains reduced exercise capacity. SSRI affects endurance type exercises in terms of prolonged time to exhaustion and task failure and impacts cognitive skills. In a neuromuscular context central and peripheral fatigue effects are differentiated by comparing stimulated and voluntary muscle activations. No study since now has ever looked for coherences between neuromuscular fatigue effects and the contribution of the serotonergic system.The purpose of the presented study was to identify the role of the serotonergic system within a neuromuscular fatigue protocol which involved a pre – post maximum contraction approach.Resultsi.) the protocol caused distinct central and peripheral neuromuscular fatigue effectsii.) paroxetine administration had no significant effect on any of the fatigue parametersConclusionsParoxetine is known to firstly inhibit serotonin release after activation of somatodentritic 5-HT1A autoreceptors, thus deteriorating the presynaptic neurotransmission. However these findings of Weicker et al. 2000 were not evident in our results. They rather support the findings of Meussen et al. 2001 who did not find an interference of SSRI with performance. The analysis of data on chronic SSRI administration will probably yield neuromuscular effects which can be attributed to augmented serotonin availability.References Weicker, H., & Str{\"u}der, H. (2001). Amino Acids.Meeusen, R., et al. (2000) Int J Sports Med.",
author = "Axel Knicker and Sarah Buscherm{\"o}hle and Thorsten Schiffer and Hannes Fricke and Str{\"u}der, {Heiko Klaus}",
year = "2014",
language = "English",
editor = "A. DeHaan",
booktitle = "19th Annual Congress of the European College of Sport Science in Amsterdam 2014",
publisher = "Taylor and Francis",
note = "Annual Congress of the European Colleg of Sport Science ; Conference date: 02-07-2014 Through 05-07-2014",

}

RIS

TY - CHAP

T1 - Acute effects of Paroxetin administration on parameters of neuromuscular fatigue

AU - Knicker, Axel

AU - Buschermöhle, Sarah

AU - Schiffer, Thorsten

AU - Fricke, Hannes

AU - Strüder, Heiko Klaus

N1 - Conference code: 19

PY - 2014

Y1 - 2014

N2 - The serotonergic system is known to modulate central fatigue manifestations. Paroxetin (SSRI) is known to inhibit serotonin release, deteriorate presynaptic neurotransmission and explains reduced exercise capacity. SSRI affects endurance type exercises in terms of prolonged time to exhaustion and task failure and impacts cognitive skills. In a neuromuscular context central and peripheral fatigue effects are differentiated by comparing stimulated and voluntary muscle activations. No study since now has ever looked for coherences between neuromuscular fatigue effects and the contribution of the serotonergic system.The purpose of the presented study was to identify the role of the serotonergic system within a neuromuscular fatigue protocol which involved a pre – post maximum contraction approach.Resultsi.) the protocol caused distinct central and peripheral neuromuscular fatigue effectsii.) paroxetine administration had no significant effect on any of the fatigue parametersConclusionsParoxetine is known to firstly inhibit serotonin release after activation of somatodentritic 5-HT1A autoreceptors, thus deteriorating the presynaptic neurotransmission. However these findings of Weicker et al. 2000 were not evident in our results. They rather support the findings of Meussen et al. 2001 who did not find an interference of SSRI with performance. The analysis of data on chronic SSRI administration will probably yield neuromuscular effects which can be attributed to augmented serotonin availability.References Weicker, H., & Strüder, H. (2001). Amino Acids.Meeusen, R., et al. (2000) Int J Sports Med.

AB - The serotonergic system is known to modulate central fatigue manifestations. Paroxetin (SSRI) is known to inhibit serotonin release, deteriorate presynaptic neurotransmission and explains reduced exercise capacity. SSRI affects endurance type exercises in terms of prolonged time to exhaustion and task failure and impacts cognitive skills. In a neuromuscular context central and peripheral fatigue effects are differentiated by comparing stimulated and voluntary muscle activations. No study since now has ever looked for coherences between neuromuscular fatigue effects and the contribution of the serotonergic system.The purpose of the presented study was to identify the role of the serotonergic system within a neuromuscular fatigue protocol which involved a pre – post maximum contraction approach.Resultsi.) the protocol caused distinct central and peripheral neuromuscular fatigue effectsii.) paroxetine administration had no significant effect on any of the fatigue parametersConclusionsParoxetine is known to firstly inhibit serotonin release after activation of somatodentritic 5-HT1A autoreceptors, thus deteriorating the presynaptic neurotransmission. However these findings of Weicker et al. 2000 were not evident in our results. They rather support the findings of Meussen et al. 2001 who did not find an interference of SSRI with performance. The analysis of data on chronic SSRI administration will probably yield neuromuscular effects which can be attributed to augmented serotonin availability.References Weicker, H., & Strüder, H. (2001). Amino Acids.Meeusen, R., et al. (2000) Int J Sports Med.

M3 - Conference contribution - Published abstract for conference with selection process

BT - 19th Annual Congress of the European College of Sport Science in Amsterdam 2014

A2 - DeHaan, A.

PB - Taylor and Francis

T2 - Annual Congress of the European Colleg of Sport Science

Y2 - 2 July 2014 through 5 July 2014

ER -

ID: 209810