Acute high-intensity aerobic exercise affects brain-derived neurotrophic factor in mild cognitive impairment: a randomised controlled study

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Acute high-intensity aerobic exercise affects brain-derived neurotrophic factor in mild cognitive impairment : a randomised controlled study. / Devenney, Kate E; Guinan, Emer M; Kelly, Áine M; Mota, Bibiana C; Walsh, Cathal; Olde Rikkert, Marcel; Schneider, Stefan; Lawlor, Brian.

In: BMJ open sport & exercise medicine, Vol. 5, No. 1, e000499, 2019.

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@article{907754241a1f4bd18885f665f998474a,
title = "Acute high-intensity aerobic exercise affects brain-derived neurotrophic factor in mild cognitive impairment: a randomised controlled study",
abstract = "Objective: To investigate the brain-derived neurotrophic factor (BDNF) and cognitive response to a short bout of high-intensity aerobic exercise in older adults with mild cognitive impairment (MCI).Methods: Participants were randomised to one of two testing schedules, completing either a standardised exercise test (group A) or a resting control condition (group B). Blood sampling and cognitive measures (visuospatial learning and memory, sustained attention and executive function) were collected at baseline (T1) and postintervention (T2). An additional measurement of study outcomes was collected after exercise (T3) in group B only.Results: 64 participants (female 53.2%, mean age 70.5±6.3 years) with MCI were recruited. From T1 to T2, serum BDNF (sBDNF) concentration increased in group A (n=35) (median (Md) 4564.61±IQR 5737.23 pg/mL to Md 5173.27±5997.54 pg/mL) and decreased in group B (Md 4593.74±9558.29 pg/mL to Md 3974.66±3668.22 pg/mL) (between-group difference p=0.024, effect size r=0.3). The control group made fewer errors on the sustained attention task compared with the exercise group (p=0.025). Measures of visuospatial learning and memory or executive function did not change significantly between groups.Conclusion: This study is the first to show that a short bout of high-intensity aerobic exercise increases peripheral sBDNF in a population with MCI. However, acute exercise did not improve cognitive performance.",
author = "Devenney, {Kate E} and Guinan, {Emer M} and Kelly, {{\'A}ine M} and Mota, {Bibiana C} and Cathal Walsh and {Olde Rikkert}, Marcel and Stefan Schneider and Brian Lawlor",
year = "2019",
doi = "10.1136/bmjsem-2018-000499",
language = "English",
volume = "5",
journal = "BMJ open sport & exercise medicine",
issn = "2055-7647",
publisher = "BMJ Publishing Group",
number = "1",

}

RIS

TY - JOUR

T1 - Acute high-intensity aerobic exercise affects brain-derived neurotrophic factor in mild cognitive impairment

T2 - a randomised controlled study

AU - Devenney, Kate E

AU - Guinan, Emer M

AU - Kelly, Áine M

AU - Mota, Bibiana C

AU - Walsh, Cathal

AU - Olde Rikkert, Marcel

AU - Schneider, Stefan

AU - Lawlor, Brian

PY - 2019

Y1 - 2019

N2 - Objective: To investigate the brain-derived neurotrophic factor (BDNF) and cognitive response to a short bout of high-intensity aerobic exercise in older adults with mild cognitive impairment (MCI).Methods: Participants were randomised to one of two testing schedules, completing either a standardised exercise test (group A) or a resting control condition (group B). Blood sampling and cognitive measures (visuospatial learning and memory, sustained attention and executive function) were collected at baseline (T1) and postintervention (T2). An additional measurement of study outcomes was collected after exercise (T3) in group B only.Results: 64 participants (female 53.2%, mean age 70.5±6.3 years) with MCI were recruited. From T1 to T2, serum BDNF (sBDNF) concentration increased in group A (n=35) (median (Md) 4564.61±IQR 5737.23 pg/mL to Md 5173.27±5997.54 pg/mL) and decreased in group B (Md 4593.74±9558.29 pg/mL to Md 3974.66±3668.22 pg/mL) (between-group difference p=0.024, effect size r=0.3). The control group made fewer errors on the sustained attention task compared with the exercise group (p=0.025). Measures of visuospatial learning and memory or executive function did not change significantly between groups.Conclusion: This study is the first to show that a short bout of high-intensity aerobic exercise increases peripheral sBDNF in a population with MCI. However, acute exercise did not improve cognitive performance.

AB - Objective: To investigate the brain-derived neurotrophic factor (BDNF) and cognitive response to a short bout of high-intensity aerobic exercise in older adults with mild cognitive impairment (MCI).Methods: Participants were randomised to one of two testing schedules, completing either a standardised exercise test (group A) or a resting control condition (group B). Blood sampling and cognitive measures (visuospatial learning and memory, sustained attention and executive function) were collected at baseline (T1) and postintervention (T2). An additional measurement of study outcomes was collected after exercise (T3) in group B only.Results: 64 participants (female 53.2%, mean age 70.5±6.3 years) with MCI were recruited. From T1 to T2, serum BDNF (sBDNF) concentration increased in group A (n=35) (median (Md) 4564.61±IQR 5737.23 pg/mL to Md 5173.27±5997.54 pg/mL) and decreased in group B (Md 4593.74±9558.29 pg/mL to Md 3974.66±3668.22 pg/mL) (between-group difference p=0.024, effect size r=0.3). The control group made fewer errors on the sustained attention task compared with the exercise group (p=0.025). Measures of visuospatial learning and memory or executive function did not change significantly between groups.Conclusion: This study is the first to show that a short bout of high-intensity aerobic exercise increases peripheral sBDNF in a population with MCI. However, acute exercise did not improve cognitive performance.

U2 - 10.1136/bmjsem-2018-000499

DO - 10.1136/bmjsem-2018-000499

M3 - Journal articles

C2 - 31258928

VL - 5

JO - BMJ open sport & exercise medicine

JF - BMJ open sport & exercise medicine

SN - 2055-7647

IS - 1

M1 - e000499

ER -

ID: 5335525