Acute hypertrophic but not maximal strength loading transiently enhances the kynurenine pathway towards kynurenic acid

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@article{7c17eddfbb8b4900905e45a3a4d3989c,
title = "Acute hypertrophic but not maximal strength loading transiently enhances the kynurenine pathway towards kynurenic acid",
abstract = "PURPOSE: Due to distinct immuno- and neuro-modulatory properties, growing research interest focuses on exercise-induced alterations of the kynurenine (KYN) pathway in healthy and clinical populations. To date, knowledge about the impact of different acute strength exercise modalities on the KYN pathway is scarce. Therefore, we investigated the acute effects of hypertrophic (HYP) compared to maximal (MAX) strength loadings on the KYN pathway regulation.METHODS: Blood samples of twelve healthy males (mean age and weight: 23.5 ± 3.2 years; 77.5 ± 7.5 kg) were collected before (T0), immediately after (T1), and 1 h after completion (T2) of HYP (5 sets with 10 repetitions at 80% of 1RM) and MAX (15 sets with 1RM) loadings performed in a randomized cross-over design. Serum concentrations of tryptophan (TRP), KYN, kynurenic acid (KA), and quinolinic acid (QA) were assessed using high-performance liquid chromatography.RESULTS: The KA/KYN ratio increased from T0 to T1 (p = 0.01) and decreased from T1 to T2 (p = 0.011) in HYP, while it was maintained within MAX. Compared to MAX, serum concentrations of KA were greater in HYP at T1 (p = 0.014). Moreover, the QA/KA ratio was significantly lower in HYP than in MAX at T1 (p = 0.002).CONCLUSION: Acute HYP loading led to increases in the metabolic flux yielding KA, thereby possibly promoting immunosuppression and neuroprotection. Our findings emphasize the potential of acute HYP exercise as short-term modulator of KYN pathway downstream to KA in healthy males and need to be proven in other samples.",
keywords = "Acute exercise, Kynurenic acid, Kynurenines, Resistance exercise, Strenuous exercise, Tryptophan metabolism",
author = "Niklas Joisten and Moritz Schumann and Alexander Schenk and David Walzik and Nils Freitag and Andre Knoop and Mario Thevis and Wilhelm Bloch and Philipp Zimmer",
year = "2020",
month = jun,
day = "1",
doi = "10.1007/s00421-020-04375-9",
language = "English",
volume = "120",
pages = "1429--1436",
journal = "European journal of applied physiology",
issn = "1439-6319",
publisher = "Springer Verlag",
number = "6",

}

RIS

TY - JOUR

T1 - Acute hypertrophic but not maximal strength loading transiently enhances the kynurenine pathway towards kynurenic acid

AU - Joisten, Niklas

AU - Schumann, Moritz

AU - Schenk, Alexander

AU - Walzik, David

AU - Freitag, Nils

AU - Knoop, Andre

AU - Thevis, Mario

AU - Bloch, Wilhelm

AU - Zimmer, Philipp

PY - 2020/6/1

Y1 - 2020/6/1

N2 - PURPOSE: Due to distinct immuno- and neuro-modulatory properties, growing research interest focuses on exercise-induced alterations of the kynurenine (KYN) pathway in healthy and clinical populations. To date, knowledge about the impact of different acute strength exercise modalities on the KYN pathway is scarce. Therefore, we investigated the acute effects of hypertrophic (HYP) compared to maximal (MAX) strength loadings on the KYN pathway regulation.METHODS: Blood samples of twelve healthy males (mean age and weight: 23.5 ± 3.2 years; 77.5 ± 7.5 kg) were collected before (T0), immediately after (T1), and 1 h after completion (T2) of HYP (5 sets with 10 repetitions at 80% of 1RM) and MAX (15 sets with 1RM) loadings performed in a randomized cross-over design. Serum concentrations of tryptophan (TRP), KYN, kynurenic acid (KA), and quinolinic acid (QA) were assessed using high-performance liquid chromatography.RESULTS: The KA/KYN ratio increased from T0 to T1 (p = 0.01) and decreased from T1 to T2 (p = 0.011) in HYP, while it was maintained within MAX. Compared to MAX, serum concentrations of KA were greater in HYP at T1 (p = 0.014). Moreover, the QA/KA ratio was significantly lower in HYP than in MAX at T1 (p = 0.002).CONCLUSION: Acute HYP loading led to increases in the metabolic flux yielding KA, thereby possibly promoting immunosuppression and neuroprotection. Our findings emphasize the potential of acute HYP exercise as short-term modulator of KYN pathway downstream to KA in healthy males and need to be proven in other samples.

AB - PURPOSE: Due to distinct immuno- and neuro-modulatory properties, growing research interest focuses on exercise-induced alterations of the kynurenine (KYN) pathway in healthy and clinical populations. To date, knowledge about the impact of different acute strength exercise modalities on the KYN pathway is scarce. Therefore, we investigated the acute effects of hypertrophic (HYP) compared to maximal (MAX) strength loadings on the KYN pathway regulation.METHODS: Blood samples of twelve healthy males (mean age and weight: 23.5 ± 3.2 years; 77.5 ± 7.5 kg) were collected before (T0), immediately after (T1), and 1 h after completion (T2) of HYP (5 sets with 10 repetitions at 80% of 1RM) and MAX (15 sets with 1RM) loadings performed in a randomized cross-over design. Serum concentrations of tryptophan (TRP), KYN, kynurenic acid (KA), and quinolinic acid (QA) were assessed using high-performance liquid chromatography.RESULTS: The KA/KYN ratio increased from T0 to T1 (p = 0.01) and decreased from T1 to T2 (p = 0.011) in HYP, while it was maintained within MAX. Compared to MAX, serum concentrations of KA were greater in HYP at T1 (p = 0.014). Moreover, the QA/KA ratio was significantly lower in HYP than in MAX at T1 (p = 0.002).CONCLUSION: Acute HYP loading led to increases in the metabolic flux yielding KA, thereby possibly promoting immunosuppression and neuroprotection. Our findings emphasize the potential of acute HYP exercise as short-term modulator of KYN pathway downstream to KA in healthy males and need to be proven in other samples.

KW - Acute exercise

KW - Kynurenic acid

KW - Kynurenines

KW - Resistance exercise

KW - Strenuous exercise

KW - Tryptophan metabolism

UR - https://www.mendeley.com/catalogue/e542b7db-21e1-3f76-96b1-1f3419d1304b/

U2 - 10.1007/s00421-020-04375-9

DO - 10.1007/s00421-020-04375-9

M3 - Journal articles

C2 - 32306154

VL - 120

SP - 1429

EP - 1436

JO - European journal of applied physiology

JF - European journal of applied physiology

SN - 1439-6319

IS - 6

ER -

ID: 5215243