Auditory event-related potentials in individuals with subjective and mild cognitive impairment

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Auditory event-related potentials in individuals with subjective and mild cognitive impairment. / NeuroExercise Study Group.

In: Behavioural brain research, Vol. 391, 112700, 2020.

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@article{7fa310d795c24f47a3272131405a7518,
title = "Auditory event-related potentials in individuals with subjective and mild cognitive impairment",
abstract = "OBJECTIVE: The analysis of event-related potentials (ERPs) is a useful tool to differentiate between healthy older adults, and individuals with mild cognitive impairment (MCI). Less is known about the ERPs' sensitivity of differentiating between individuals with subjective cognitive impairment (SCI) and MCI, as early evidence indicates similar brain alterations between these two groups. In order, to establish tests that are sensitive to subclinical impairment, this study compared auditory evoked ERPs between individuals with SCI and MCI.METHODS: Besides assessing cognitive performance in four neuropsychological tests (Trail Making Test A + B, verbal fluency letter and category task), latency and amplitude of ERP components evoked by an auditory oddball paradigm were compared between two groups of either individuals with SCI (n = 13) or MCI (n = 13).RESULTS: While individuals with MCI performed significantly worse in all neuropsychological tests (TMT A: p = 0.001, Cohen's d = 1.5; TMT B: p = 0.030, Cohen's d = 0.94; verbal fluency letter: p = 0.0011, Cohen's d = 1.08; verbal fluency category: p = 0.038; Cohen's d = 0.86), no significant differences (p > 0.05) were found in ERP components with small to moderate effect sizes (Cohen's d ranged between 0.11 - 0.59).CONCLUSION: ERPs evoked by an auditory oddball paradigm lack sensitivity to differentiate between individuals with SCI and MCI, although significant differences in cognitive performance were detected by neuropsychological tests. Similar pathophysiological brain alterations may limit utility of ERPs as indicated by previous research and results of this study. Cognitively more challenging tasks than the auditory oddball paradigm may be considered by future investigations.",
author = "{NeuroExercise Study Group} and Tim Stuckenschneider and Askew, {Christopher D} and Jan Weber and Vera Abeln and Stefanie R{\"u}diger and Summers, {Mathew J} and Stefan Schneider",
note = "Copyright {\textcopyright} 2020. Published by Elsevier B.V.",
year = "2020",
doi = "10.1016/j.bbr.2020.112700",
language = "English",
volume = "391",
journal = "Behavioural brain research",
issn = "0166-4328",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Auditory event-related potentials in individuals with subjective and mild cognitive impairment

AU - NeuroExercise Study Group

AU - Stuckenschneider, Tim

AU - Askew, Christopher D

AU - Weber, Jan

AU - Abeln, Vera

AU - Rüdiger, Stefanie

AU - Summers, Mathew J

AU - Schneider, Stefan

N1 - Copyright © 2020. Published by Elsevier B.V.

PY - 2020

Y1 - 2020

N2 - OBJECTIVE: The analysis of event-related potentials (ERPs) is a useful tool to differentiate between healthy older adults, and individuals with mild cognitive impairment (MCI). Less is known about the ERPs' sensitivity of differentiating between individuals with subjective cognitive impairment (SCI) and MCI, as early evidence indicates similar brain alterations between these two groups. In order, to establish tests that are sensitive to subclinical impairment, this study compared auditory evoked ERPs between individuals with SCI and MCI.METHODS: Besides assessing cognitive performance in four neuropsychological tests (Trail Making Test A + B, verbal fluency letter and category task), latency and amplitude of ERP components evoked by an auditory oddball paradigm were compared between two groups of either individuals with SCI (n = 13) or MCI (n = 13).RESULTS: While individuals with MCI performed significantly worse in all neuropsychological tests (TMT A: p = 0.001, Cohen's d = 1.5; TMT B: p = 0.030, Cohen's d = 0.94; verbal fluency letter: p = 0.0011, Cohen's d = 1.08; verbal fluency category: p = 0.038; Cohen's d = 0.86), no significant differences (p > 0.05) were found in ERP components with small to moderate effect sizes (Cohen's d ranged between 0.11 - 0.59).CONCLUSION: ERPs evoked by an auditory oddball paradigm lack sensitivity to differentiate between individuals with SCI and MCI, although significant differences in cognitive performance were detected by neuropsychological tests. Similar pathophysiological brain alterations may limit utility of ERPs as indicated by previous research and results of this study. Cognitively more challenging tasks than the auditory oddball paradigm may be considered by future investigations.

AB - OBJECTIVE: The analysis of event-related potentials (ERPs) is a useful tool to differentiate between healthy older adults, and individuals with mild cognitive impairment (MCI). Less is known about the ERPs' sensitivity of differentiating between individuals with subjective cognitive impairment (SCI) and MCI, as early evidence indicates similar brain alterations between these two groups. In order, to establish tests that are sensitive to subclinical impairment, this study compared auditory evoked ERPs between individuals with SCI and MCI.METHODS: Besides assessing cognitive performance in four neuropsychological tests (Trail Making Test A + B, verbal fluency letter and category task), latency and amplitude of ERP components evoked by an auditory oddball paradigm were compared between two groups of either individuals with SCI (n = 13) or MCI (n = 13).RESULTS: While individuals with MCI performed significantly worse in all neuropsychological tests (TMT A: p = 0.001, Cohen's d = 1.5; TMT B: p = 0.030, Cohen's d = 0.94; verbal fluency letter: p = 0.0011, Cohen's d = 1.08; verbal fluency category: p = 0.038; Cohen's d = 0.86), no significant differences (p > 0.05) were found in ERP components with small to moderate effect sizes (Cohen's d ranged between 0.11 - 0.59).CONCLUSION: ERPs evoked by an auditory oddball paradigm lack sensitivity to differentiate between individuals with SCI and MCI, although significant differences in cognitive performance were detected by neuropsychological tests. Similar pathophysiological brain alterations may limit utility of ERPs as indicated by previous research and results of this study. Cognitively more challenging tasks than the auditory oddball paradigm may be considered by future investigations.

U2 - 10.1016/j.bbr.2020.112700

DO - 10.1016/j.bbr.2020.112700

M3 - Journal articles

C2 - 32446915

VL - 391

JO - Behavioural brain research

JF - Behavioural brain research

SN - 0166-4328

M1 - 112700

ER -

ID: 5283260