Blood pressure-lowering effect of nebivolol in hypertensive patients with type 2 diabetes mellitus: the YESTONO study

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Blood pressure-lowering effect of nebivolol in hypertensive patients with type 2 diabetes mellitus : the YESTONO study. / Schmidt, Andre C; Graf, Christine; Brixius, Klara; Scholze, Juergen.

In: Clinical drug investigation, Vol. 27, No. 12, 01.01.2007, p. 841-849.

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@article{f0a5dd37937148d38dc6f77eba2c1d3a,
title = "Blood pressure-lowering effect of nebivolol in hypertensive patients with type 2 diabetes mellitus: the YESTONO study",
abstract = "BACKGROUND: Effective blood pressure (BP)-lowering therapy is regarded as the most important intervention in diabetes mellitus. Nebivolol is commonly used for the treatment of hypertension, but to date there has been no study of its use in a large population of hypertensive patients with type 2 diabetes mellitus.METHODS: A prospective, open-label, multicentre, post-marketing surveillance study was conducted in 2838 patients with arterial hypertension requiring intervention and concomitant type 2 diabetes, with or without other diseases. The therapeutic agent was nebivolol, either as monotherapy or as add-on therapy to other antihypertensive agents, over a minimum period of 3 months, with the primary endpoint being achievement of target BPs, that is, systolic BP < or = 140 mm Hg and diastolic BP < or = 90 mm Hg. Other endpoints were changes in metabolic parameters, effects on physical capability and tolerability during treatment. Statistical analysis was prospectively planned and conducted on an intention-to-treat basis.RESULTS: Mean (SD) BP decreased from 156 (15.3)/92 (9.4)mm Hg to 135 (11)/81 (6.6)mm Hg during the treatment period, while mean (SD) heart rate decreased from 79 (10) to 71 (7) beats/min. Strict reduction of BP was associated with improvements in most metabolic parameters, including lipid levels, glycosylated haemoglobin (HbA(1c)) and microalbuminuria. Maximum physical capability improved modestly. Most patients (85%) received nebivolol 5 mg/day.CONCLUSIONS: Strict BP reduction in hypertensive patients with type 2 diabetes with or without other concomitant cardiovascular diseases is achieved with nebivolol 5 mg/day in most patients. The benefits of lowering BP with use of nebivolol are associated with improvements in most metabolic parameters and in maximum physical capability.",
keywords = "Adrenergic beta-Antagonists, Adult, Aged, Aged, 80 and over, Albuminuria, Antihypertensive Agents, Benzopyrans, Blood Pressure, Diabetes Mellitus, Type 2, Drug Therapy, Combination, Ethanolamines, Exercise Tolerance, Female, Heart Rate, Hemoglobin A, Glycosylated, Humans, Hypertension, Lipids, Male, Middle Aged, Product Surveillance, Postmarketing, Prospective Studies, Treatment Outcome",
author = "Schmidt, {Andre C} and Christine Graf and Klara Brixius and Juergen Scholze",
year = "2007",
month = jan,
day = "1",
language = "English",
volume = "27",
pages = "841--849",
journal = "Clinical drug investigation",
issn = "1173-2563",
publisher = "Adis International Ltd",
number = "12",

}

RIS

TY - JOUR

T1 - Blood pressure-lowering effect of nebivolol in hypertensive patients with type 2 diabetes mellitus

T2 - the YESTONO study

AU - Schmidt, Andre C

AU - Graf, Christine

AU - Brixius, Klara

AU - Scholze, Juergen

PY - 2007/1/1

Y1 - 2007/1/1

N2 - BACKGROUND: Effective blood pressure (BP)-lowering therapy is regarded as the most important intervention in diabetes mellitus. Nebivolol is commonly used for the treatment of hypertension, but to date there has been no study of its use in a large population of hypertensive patients with type 2 diabetes mellitus.METHODS: A prospective, open-label, multicentre, post-marketing surveillance study was conducted in 2838 patients with arterial hypertension requiring intervention and concomitant type 2 diabetes, with or without other diseases. The therapeutic agent was nebivolol, either as monotherapy or as add-on therapy to other antihypertensive agents, over a minimum period of 3 months, with the primary endpoint being achievement of target BPs, that is, systolic BP < or = 140 mm Hg and diastolic BP < or = 90 mm Hg. Other endpoints were changes in metabolic parameters, effects on physical capability and tolerability during treatment. Statistical analysis was prospectively planned and conducted on an intention-to-treat basis.RESULTS: Mean (SD) BP decreased from 156 (15.3)/92 (9.4)mm Hg to 135 (11)/81 (6.6)mm Hg during the treatment period, while mean (SD) heart rate decreased from 79 (10) to 71 (7) beats/min. Strict reduction of BP was associated with improvements in most metabolic parameters, including lipid levels, glycosylated haemoglobin (HbA(1c)) and microalbuminuria. Maximum physical capability improved modestly. Most patients (85%) received nebivolol 5 mg/day.CONCLUSIONS: Strict BP reduction in hypertensive patients with type 2 diabetes with or without other concomitant cardiovascular diseases is achieved with nebivolol 5 mg/day in most patients. The benefits of lowering BP with use of nebivolol are associated with improvements in most metabolic parameters and in maximum physical capability.

AB - BACKGROUND: Effective blood pressure (BP)-lowering therapy is regarded as the most important intervention in diabetes mellitus. Nebivolol is commonly used for the treatment of hypertension, but to date there has been no study of its use in a large population of hypertensive patients with type 2 diabetes mellitus.METHODS: A prospective, open-label, multicentre, post-marketing surveillance study was conducted in 2838 patients with arterial hypertension requiring intervention and concomitant type 2 diabetes, with or without other diseases. The therapeutic agent was nebivolol, either as monotherapy or as add-on therapy to other antihypertensive agents, over a minimum period of 3 months, with the primary endpoint being achievement of target BPs, that is, systolic BP < or = 140 mm Hg and diastolic BP < or = 90 mm Hg. Other endpoints were changes in metabolic parameters, effects on physical capability and tolerability during treatment. Statistical analysis was prospectively planned and conducted on an intention-to-treat basis.RESULTS: Mean (SD) BP decreased from 156 (15.3)/92 (9.4)mm Hg to 135 (11)/81 (6.6)mm Hg during the treatment period, while mean (SD) heart rate decreased from 79 (10) to 71 (7) beats/min. Strict reduction of BP was associated with improvements in most metabolic parameters, including lipid levels, glycosylated haemoglobin (HbA(1c)) and microalbuminuria. Maximum physical capability improved modestly. Most patients (85%) received nebivolol 5 mg/day.CONCLUSIONS: Strict BP reduction in hypertensive patients with type 2 diabetes with or without other concomitant cardiovascular diseases is achieved with nebivolol 5 mg/day in most patients. The benefits of lowering BP with use of nebivolol are associated with improvements in most metabolic parameters and in maximum physical capability.

KW - Adrenergic beta-Antagonists

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Albuminuria

KW - Antihypertensive Agents

KW - Benzopyrans

KW - Blood Pressure

KW - Diabetes Mellitus, Type 2

KW - Drug Therapy, Combination

KW - Ethanolamines

KW - Exercise Tolerance

KW - Female

KW - Heart Rate

KW - Hemoglobin A, Glycosylated

KW - Humans

KW - Hypertension

KW - Lipids

KW - Male

KW - Middle Aged

KW - Product Surveillance, Postmarketing

KW - Prospective Studies

KW - Treatment Outcome

M3 - Journal articles

C2 - 18020542

VL - 27

SP - 841

EP - 849

JO - Clinical drug investigation

JF - Clinical drug investigation

SN - 1173-2563

IS - 12

ER -

ID: 316274