Chemotherapie-induzierte Polyneuropathie

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Chemotherapy-induced peripheral neuropathy (CIPN) is a common and relevant side effect of antineoplastic agents such as cisplatin, paclitaxel, vincristine and bortezomib. Over the last years, significant progress has been achieved in elucidating the underlying pathomechanisms of CIPN using both in vivo and in vitro models. These studies suggest that mitochondrial toxicity, disturbed axonal transport, toxic effects on Schwann cells and activation of the immune system contribute to the pathogenesis of CIPN. This review provides an overview of the current pathogenetic concepts of CIPN. In addition, experimental approaches that aim at preventing or ameliorating neurotoxic effects of antineoplastic agents are discussed.

Translated title of the contributionChemotherapy-induced Peripheral Neuropathy
Original languageGerman
JournalFortschritte der Neurologie-Psychiatrie
Volume83
Issue number8
Pages (from-to)427-436
Number of pages10
ISSN0720-4299
DOIs
Publication statusPublished - 08.2015

ID: 1552080

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