Ecdysteroids as non-conventional anabolic agent: performance enhancement by ecdysterone supplementation in humans

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Ecdysteroids as non-conventional anabolic agent : performance enhancement by ecdysterone supplementation in humans. / Isenmann, Eduard; Ambrosio, Gabriella; Joseph, Jan Felix; Mazzarino, Monica; de la Torre, Xavier; Zimmer, Philipp; Kazlauskas, Rymantas; Goebel, Catrin; Botrè, Francesco; Diel, Patrick; Parr, Maria Kristina.

In: Archives of toxicology, Vol. 93, No. 7, 07.2019, p. 1807-1816.

Research output: Contribution to journalJournal articlesResearchpeer-review

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Isenmann, E, Ambrosio, G, Joseph, JF, Mazzarino, M, de la Torre, X, Zimmer, P, Kazlauskas, R, Goebel, C, Botrè, F, Diel, P & Parr, MK 2019, 'Ecdysteroids as non-conventional anabolic agent: performance enhancement by ecdysterone supplementation in humans', Archives of toxicology, vol. 93, no. 7, pp. 1807-1816. https://doi.org/10.1007/s00204-019-02490-x

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@article{a1e0a23a16b04aed9703b5df2fe9cc01,
title = "Ecdysteroids as non-conventional anabolic agent: performance enhancement by ecdysterone supplementation in humans",
abstract = "Recent studies suggest that the anabolic effect of ecdysterone, a naturally occurring steroid hormone claimed to enhance physical performance, is mediated by estrogen receptor (ER) binding. In comparison with the prohibited anabolic agents (e.g., metandienone and others), ecdysterone revealed to be even more effective in a recent study performed in rats. However, scientific studies in humans are very rarely accessible. Thus, our project aimed at investigating the effects of ecdysterone-containing products on human sport exercise. A 10-week intervention study of strength training of young men (n = 46) was carried out. Different doses of ecdysterone-containing supplements have been administered during the study to evaluate the performance-enhancing effect. Analysis of blood and urine samples for ecdysterone and potential biomarkers of performance enhancement has been conducted. To ensure the specificity of the effects measured, a comprehensive screening for prohibited performance-enhancing substances was also carried out. Furthermore, the administered supplement has been tested for the absence of anabolic steroid contaminations prior to administration. Significantly higher increases in muscle mass were observed in those participants that were dosed with ecdysterone. The same hypertrophic effects were also detected in vitro in C2C12 myotubes. Even more relevant with respect to sports performance, significantly more pronounced increases in one-repetition bench press performance were observed. No increase in biomarkers for liver or kidney toxicity was noticed. These data underline the effectivity of an ecdysterone supplementation with respect to sports performance. Our results strongly suggest the inclusion of ecdysterone in the list of prohibited substances and methods in sports in class S1.2 {"}other anabolic agents{"}.",
author = "Eduard Isenmann and Gabriella Ambrosio and Joseph, {Jan Felix} and Monica Mazzarino and {de la Torre}, Xavier and Philipp Zimmer and Rymantas Kazlauskas and Catrin Goebel and Francesco Botr{\`e} and Patrick Diel and Parr, {Maria Kristina}",
year = "2019",
month = "7",
doi = "10.1007/s00204-019-02490-x",
language = "English",
volume = "93",
pages = "1807--1816",
journal = "Archives of toxicology",
issn = "0340-5761",
publisher = "Springer Verlag",
number = "7",

}

RIS

TY - JOUR

T1 - Ecdysteroids as non-conventional anabolic agent

T2 - performance enhancement by ecdysterone supplementation in humans

AU - Isenmann, Eduard

AU - Ambrosio, Gabriella

AU - Joseph, Jan Felix

AU - Mazzarino, Monica

AU - de la Torre, Xavier

AU - Zimmer, Philipp

AU - Kazlauskas, Rymantas

AU - Goebel, Catrin

AU - Botrè, Francesco

AU - Diel, Patrick

AU - Parr, Maria Kristina

PY - 2019/7

Y1 - 2019/7

N2 - Recent studies suggest that the anabolic effect of ecdysterone, a naturally occurring steroid hormone claimed to enhance physical performance, is mediated by estrogen receptor (ER) binding. In comparison with the prohibited anabolic agents (e.g., metandienone and others), ecdysterone revealed to be even more effective in a recent study performed in rats. However, scientific studies in humans are very rarely accessible. Thus, our project aimed at investigating the effects of ecdysterone-containing products on human sport exercise. A 10-week intervention study of strength training of young men (n = 46) was carried out. Different doses of ecdysterone-containing supplements have been administered during the study to evaluate the performance-enhancing effect. Analysis of blood and urine samples for ecdysterone and potential biomarkers of performance enhancement has been conducted. To ensure the specificity of the effects measured, a comprehensive screening for prohibited performance-enhancing substances was also carried out. Furthermore, the administered supplement has been tested for the absence of anabolic steroid contaminations prior to administration. Significantly higher increases in muscle mass were observed in those participants that were dosed with ecdysterone. The same hypertrophic effects were also detected in vitro in C2C12 myotubes. Even more relevant with respect to sports performance, significantly more pronounced increases in one-repetition bench press performance were observed. No increase in biomarkers for liver or kidney toxicity was noticed. These data underline the effectivity of an ecdysterone supplementation with respect to sports performance. Our results strongly suggest the inclusion of ecdysterone in the list of prohibited substances and methods in sports in class S1.2 "other anabolic agents".

AB - Recent studies suggest that the anabolic effect of ecdysterone, a naturally occurring steroid hormone claimed to enhance physical performance, is mediated by estrogen receptor (ER) binding. In comparison with the prohibited anabolic agents (e.g., metandienone and others), ecdysterone revealed to be even more effective in a recent study performed in rats. However, scientific studies in humans are very rarely accessible. Thus, our project aimed at investigating the effects of ecdysterone-containing products on human sport exercise. A 10-week intervention study of strength training of young men (n = 46) was carried out. Different doses of ecdysterone-containing supplements have been administered during the study to evaluate the performance-enhancing effect. Analysis of blood and urine samples for ecdysterone and potential biomarkers of performance enhancement has been conducted. To ensure the specificity of the effects measured, a comprehensive screening for prohibited performance-enhancing substances was also carried out. Furthermore, the administered supplement has been tested for the absence of anabolic steroid contaminations prior to administration. Significantly higher increases in muscle mass were observed in those participants that were dosed with ecdysterone. The same hypertrophic effects were also detected in vitro in C2C12 myotubes. Even more relevant with respect to sports performance, significantly more pronounced increases in one-repetition bench press performance were observed. No increase in biomarkers for liver or kidney toxicity was noticed. These data underline the effectivity of an ecdysterone supplementation with respect to sports performance. Our results strongly suggest the inclusion of ecdysterone in the list of prohibited substances and methods in sports in class S1.2 "other anabolic agents".

U2 - 10.1007/s00204-019-02490-x

DO - 10.1007/s00204-019-02490-x

M3 - Journal articles

C2 - 31123801

VL - 93

SP - 1807

EP - 1816

JO - Archives of toxicology

JF - Archives of toxicology

SN - 0340-5761

IS - 7

ER -

ID: 4609959