Effect of Acute and Chronic Xenon Inhalation on Erythropoietin, Hematological Parameters, and Athletic Performance

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Effect of Acute and Chronic Xenon Inhalation on Erythropoietin, Hematological Parameters, and Athletic Performance. / Dias, Katrin A; Lawley, Justin Stevan; Gatterer, Hannes; Howden, Erin J; Sarma, Satyam; Cornwell, William K; Hearon, Christopher M; Samels, Mitchel; Everding, Braden; Shuo-Wen Liang, Allan; Hendrix, Max; Piper, Thomas; Thevis, Mario; Bruick, Richard K; Levine, Benjamin D.

In: Journal of applied physiology (Bethesda, Md. : 1985), Vol. 127, No. 6, 01.12.2019, p. 1503-1510.

Research output: Contribution to journalJournal articlesResearchpeer-review

Harvard

Dias, KA, Lawley, JS, Gatterer, H, Howden, EJ, Sarma, S, Cornwell, WK, Hearon, CM, Samels, M, Everding, B, Shuo-Wen Liang, A, Hendrix, M, Piper, T, Thevis, M, Bruick, RK & Levine, BD 2019, 'Effect of Acute and Chronic Xenon Inhalation on Erythropoietin, Hematological Parameters, and Athletic Performance', Journal of applied physiology (Bethesda, Md. : 1985), vol. 127, no. 6, pp. 1503-1510. https://doi.org/10.1152/japplphysiol.00289.2019

APA

Dias, K. A., Lawley, J. S., Gatterer, H., Howden, E. J., Sarma, S., Cornwell, W. K., Hearon, C. M., Samels, M., Everding, B., Shuo-Wen Liang, A., Hendrix, M., Piper, T., Thevis, M., Bruick, R. K., & Levine, B. D. (2019). Effect of Acute and Chronic Xenon Inhalation on Erythropoietin, Hematological Parameters, and Athletic Performance. Journal of applied physiology (Bethesda, Md. : 1985), 127(6), 1503-1510. https://doi.org/10.1152/japplphysiol.00289.2019

Vancouver

Bibtex

@article{3e4c5f2c5c184bc19331be2bf8e33597,
title = "Effect of Acute and Chronic Xenon Inhalation on Erythropoietin, Hematological Parameters, and Athletic Performance",
abstract = "This study aimed to assess the efficacy of acute subanesthetic dosages of xenon inhalation to cause erythropoiesis and determine the effect of chronic xenon dosing on hematological parameters and athletic performance. To assess the acute effects, seven subjects breathed three subanesthetic concentrations of xenon: 30% fraction of inspired xenon (FIXe) for 20 min, 50% FIXe for 5 min, and 70% FIXe for 2 min. Erythropoietin (EPO) was measured at baseline, during, and after xenon inhalation. To determine the chronic effects, eight subjects breathed 70% FIXe for 2 min on 7 consecutive days, and EPO, total blood, and plasma volume were measured. Phase II involved assessment of 12 subjects for EPO, total blood volume, maximal oxygen uptake, and 3-km time before and after random assignment to 4 wk of xenon or sham gas inhalation. FIXe 50% and 70% stimulated an increase in EPO at 6 h [+2.3 mIU/mL; 95% confidence interval (CI) 0.1-4.5; P = 0.038] and at 192 h postinhalation (+2.9 mIU/mL; 95% CI 0.6-5.1; P = 0.017), respectively. Seven consecutive days of dosing significantly elevated plasma volume (+491 mL; 95% CI 194-789; P = 0.002). Phase II showed no significant effect on EPO, hemoglobin mass, plasma volume, maximal oxygen uptake, or 3-km time. Acute exposure to subanesthetic doses of xenon caused a consistent increase in EPO, and 7 consecutive days of xenon inhalation significantly expanded plasma volume. However, this physiological response appeared to be transient, and 4 wk of xenon inhalation did not stimulate increases in plasma volume or erythropoiesis, leaving cardiorespiratory fitness and athletic performance unchanged. NEW & NOTEWORTHY This is the first study to examine each element of the cascade by which xenon inhalation is purported to take effect, starting with measurement of the hypoxia-inducible factor effector, erythropoietin, to hemoglobin mass and blood volume and athletic performance. We found that acute exposure to xenon increased serum erythropoietin concentration, although major markers of erythropoiesis remained unchanged. While daily dosing significantly expanded plasma volume, no physiological or performance benefits were apparent following 4 wk of dosing.",
keywords = "Athletic performance, Cardiorespiratory fitness, Erythropoiesis, Hemoglobin mass, Xenon",
author = "Dias, {Katrin A} and Lawley, {Justin Stevan} and Hannes Gatterer and Howden, {Erin J} and Satyam Sarma and Cornwell, {William K} and Hearon, {Christopher M} and Mitchel Samels and Braden Everding and {Shuo-Wen Liang}, Allan and Max Hendrix and Thomas Piper and Mario Thevis and Bruick, {Richard K} and Levine, {Benjamin D}",
note = "Online: 15.08.2019",
year = "2019",
month = dec,
day = "1",
doi = "10.1152/japplphysiol.00289.2019",
language = "English",
volume = "127",
pages = "1503--1510",
journal = "Journal of applied physiology (Bethesda, Md. : 1985)",
issn = "8750-7587",
publisher = "American Physiological Society",
number = "6",

}

RIS

TY - JOUR

T1 - Effect of Acute and Chronic Xenon Inhalation on Erythropoietin, Hematological Parameters, and Athletic Performance

AU - Dias, Katrin A

AU - Lawley, Justin Stevan

AU - Gatterer, Hannes

AU - Howden, Erin J

AU - Sarma, Satyam

AU - Cornwell, William K

AU - Hearon, Christopher M

AU - Samels, Mitchel

AU - Everding, Braden

AU - Shuo-Wen Liang, Allan

AU - Hendrix, Max

AU - Piper, Thomas

AU - Thevis, Mario

AU - Bruick, Richard K

AU - Levine, Benjamin D

N1 - Online: 15.08.2019

PY - 2019/12/1

Y1 - 2019/12/1

N2 - This study aimed to assess the efficacy of acute subanesthetic dosages of xenon inhalation to cause erythropoiesis and determine the effect of chronic xenon dosing on hematological parameters and athletic performance. To assess the acute effects, seven subjects breathed three subanesthetic concentrations of xenon: 30% fraction of inspired xenon (FIXe) for 20 min, 50% FIXe for 5 min, and 70% FIXe for 2 min. Erythropoietin (EPO) was measured at baseline, during, and after xenon inhalation. To determine the chronic effects, eight subjects breathed 70% FIXe for 2 min on 7 consecutive days, and EPO, total blood, and plasma volume were measured. Phase II involved assessment of 12 subjects for EPO, total blood volume, maximal oxygen uptake, and 3-km time before and after random assignment to 4 wk of xenon or sham gas inhalation. FIXe 50% and 70% stimulated an increase in EPO at 6 h [+2.3 mIU/mL; 95% confidence interval (CI) 0.1-4.5; P = 0.038] and at 192 h postinhalation (+2.9 mIU/mL; 95% CI 0.6-5.1; P = 0.017), respectively. Seven consecutive days of dosing significantly elevated plasma volume (+491 mL; 95% CI 194-789; P = 0.002). Phase II showed no significant effect on EPO, hemoglobin mass, plasma volume, maximal oxygen uptake, or 3-km time. Acute exposure to subanesthetic doses of xenon caused a consistent increase in EPO, and 7 consecutive days of xenon inhalation significantly expanded plasma volume. However, this physiological response appeared to be transient, and 4 wk of xenon inhalation did not stimulate increases in plasma volume or erythropoiesis, leaving cardiorespiratory fitness and athletic performance unchanged. NEW & NOTEWORTHY This is the first study to examine each element of the cascade by which xenon inhalation is purported to take effect, starting with measurement of the hypoxia-inducible factor effector, erythropoietin, to hemoglobin mass and blood volume and athletic performance. We found that acute exposure to xenon increased serum erythropoietin concentration, although major markers of erythropoiesis remained unchanged. While daily dosing significantly expanded plasma volume, no physiological or performance benefits were apparent following 4 wk of dosing.

AB - This study aimed to assess the efficacy of acute subanesthetic dosages of xenon inhalation to cause erythropoiesis and determine the effect of chronic xenon dosing on hematological parameters and athletic performance. To assess the acute effects, seven subjects breathed three subanesthetic concentrations of xenon: 30% fraction of inspired xenon (FIXe) for 20 min, 50% FIXe for 5 min, and 70% FIXe for 2 min. Erythropoietin (EPO) was measured at baseline, during, and after xenon inhalation. To determine the chronic effects, eight subjects breathed 70% FIXe for 2 min on 7 consecutive days, and EPO, total blood, and plasma volume were measured. Phase II involved assessment of 12 subjects for EPO, total blood volume, maximal oxygen uptake, and 3-km time before and after random assignment to 4 wk of xenon or sham gas inhalation. FIXe 50% and 70% stimulated an increase in EPO at 6 h [+2.3 mIU/mL; 95% confidence interval (CI) 0.1-4.5; P = 0.038] and at 192 h postinhalation (+2.9 mIU/mL; 95% CI 0.6-5.1; P = 0.017), respectively. Seven consecutive days of dosing significantly elevated plasma volume (+491 mL; 95% CI 194-789; P = 0.002). Phase II showed no significant effect on EPO, hemoglobin mass, plasma volume, maximal oxygen uptake, or 3-km time. Acute exposure to subanesthetic doses of xenon caused a consistent increase in EPO, and 7 consecutive days of xenon inhalation significantly expanded plasma volume. However, this physiological response appeared to be transient, and 4 wk of xenon inhalation did not stimulate increases in plasma volume or erythropoiesis, leaving cardiorespiratory fitness and athletic performance unchanged. NEW & NOTEWORTHY This is the first study to examine each element of the cascade by which xenon inhalation is purported to take effect, starting with measurement of the hypoxia-inducible factor effector, erythropoietin, to hemoglobin mass and blood volume and athletic performance. We found that acute exposure to xenon increased serum erythropoietin concentration, although major markers of erythropoiesis remained unchanged. While daily dosing significantly expanded plasma volume, no physiological or performance benefits were apparent following 4 wk of dosing.

KW - Athletic performance

KW - Cardiorespiratory fitness

KW - Erythropoiesis

KW - Hemoglobin mass

KW - Xenon

UR - https://www.mendeley.com/catalogue/65aea42a-1d2b-3b3d-aad6-e9dc75722060/

U2 - 10.1152/japplphysiol.00289.2019

DO - 10.1152/japplphysiol.00289.2019

M3 - Journal articles

C2 - 31414957

VL - 127

SP - 1503

EP - 1510

JO - Journal of applied physiology (Bethesda, Md. : 1985)

JF - Journal of applied physiology (Bethesda, Md. : 1985)

SN - 8750-7587

IS - 6

ER -

ID: 4878110