Effect of Acute and Chronic Xenon Inhalation on Erythropoietin, Hematological Parameters, and Athletic Performance

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Effect of Acute and Chronic Xenon Inhalation on Erythropoietin, Hematological Parameters, and Athletic Performance. / Dias, Katrin A; Lawley, Justin Stevan; Gatterer, Hannes; Howden, Erin J; Sarma, Satyam; Cornwell, William K; Hearon, Christopher M; Samels, Mitchel; Everding, Braden; Shuo-Wen Liang, Allan; Hendrix, Max; Piper, Thomas; Thevis, Mario; Bruick, Richard K; Levine, Benjamin D.

In: Journal of applied physiology (Bethesda, Md. : 1985), 15.08.2019.

Research output: Contribution to journalJournal articlesResearchpeer-review

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Dias, KA, Lawley, JS, Gatterer, H, Howden, EJ, Sarma, S, Cornwell, WK, Hearon, CM, Samels, M, Everding, B, Shuo-Wen Liang, A, Hendrix, M, Piper, T, Thevis, M, Bruick, RK & Levine, BD 2019, 'Effect of Acute and Chronic Xenon Inhalation on Erythropoietin, Hematological Parameters, and Athletic Performance', Journal of applied physiology (Bethesda, Md. : 1985). https://doi.org/10.1152/japplphysiol.00289.2019

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@article{3e4c5f2c5c184bc19331be2bf8e33597,
title = "Effect of Acute and Chronic Xenon Inhalation on Erythropoietin, Hematological Parameters, and Athletic Performance",
abstract = "BACKGROUND: This study aimed to assess the efficacy of acute sub-anesthetic dosages of xenon inhalation to cause erythropoiesis, and determine the effect of chronic xenon dosing on hematological parameters and athletic performance.METHODS: To assess the acute effects, 7 subjects breathed three sub-anesthetic concentrations of xenon: FiXe 30{\%} for 20 minutes, FiXe 50{\%} for 5 minutes and FiXe 70{\%} for 2 minutes. EPO was measured at baseline, during and post xenon inhalation. To determine the chronic effects, 8 subjects breathed FiXe 70{\%} for 2 minutes on 7 consecutive days, and EPO, total blood and plasma volume were measured. Phase II involved assessment of 12 subjects for EPO, total blood volume, V̇O2max, and 3km time before and after random assignment to 4 weeks of xenon or sham gas inhalation.RESULTS: FiXe 50{\%} and 70{\%} stimulated an increase in EPO at 6 hours (+2.3mIU/mL [95{\%}CI 0.1-4.5], P=0.038) and at 192 hours post inhalation (+2.9mIU/mL [95{\%}CI 0.6-5.1], P=0.017), respectively. Seven consecutive days of dosing significantly markedly elevated plasma volume (+491mL [95{\%}CI 194-789], P=0.002). Phase II showed no significant effect on EPO, hemoglobin mass, plasma volume, V̇O2max, or 3 km time.CONCLUSIONS: Acute exposure to sub-anesthetic doses of xenon caused a consistent increase in EPO, and 7 consecutive days of xenon inhalation significantly expanded plasma volume. However, this physiological response appeared to be transient and 4 weeks of xenon inhalation did not stimulate increases in plasma volume or erythropoiesis, leaving cardiorespiratory fitness and athletic performance unchanged.",
author = "Dias, {Katrin A} and Lawley, {Justin Stevan} and Hannes Gatterer and Howden, {Erin J} and Satyam Sarma and Cornwell, {William K} and Hearon, {Christopher M} and Mitchel Samels and Braden Everding and {Shuo-Wen Liang}, Allan and Max Hendrix and Thomas Piper and Mario Thevis and Bruick, {Richard K} and Levine, {Benjamin D}",
note = "Online: 15.08.2019",
year = "2019",
month = "8",
day = "15",
doi = "10.1152/japplphysiol.00289.2019",
language = "English",
journal = "Journal of applied physiology (Bethesda, Md. : 1985)",
issn = "8750-7587",
publisher = "American Physiological Society",

}

RIS

TY - JOUR

T1 - Effect of Acute and Chronic Xenon Inhalation on Erythropoietin, Hematological Parameters, and Athletic Performance

AU - Dias, Katrin A

AU - Lawley, Justin Stevan

AU - Gatterer, Hannes

AU - Howden, Erin J

AU - Sarma, Satyam

AU - Cornwell, William K

AU - Hearon, Christopher M

AU - Samels, Mitchel

AU - Everding, Braden

AU - Shuo-Wen Liang, Allan

AU - Hendrix, Max

AU - Piper, Thomas

AU - Thevis, Mario

AU - Bruick, Richard K

AU - Levine, Benjamin D

N1 - Online: 15.08.2019

PY - 2019/8/15

Y1 - 2019/8/15

N2 - BACKGROUND: This study aimed to assess the efficacy of acute sub-anesthetic dosages of xenon inhalation to cause erythropoiesis, and determine the effect of chronic xenon dosing on hematological parameters and athletic performance.METHODS: To assess the acute effects, 7 subjects breathed three sub-anesthetic concentrations of xenon: FiXe 30% for 20 minutes, FiXe 50% for 5 minutes and FiXe 70% for 2 minutes. EPO was measured at baseline, during and post xenon inhalation. To determine the chronic effects, 8 subjects breathed FiXe 70% for 2 minutes on 7 consecutive days, and EPO, total blood and plasma volume were measured. Phase II involved assessment of 12 subjects for EPO, total blood volume, V̇O2max, and 3km time before and after random assignment to 4 weeks of xenon or sham gas inhalation.RESULTS: FiXe 50% and 70% stimulated an increase in EPO at 6 hours (+2.3mIU/mL [95%CI 0.1-4.5], P=0.038) and at 192 hours post inhalation (+2.9mIU/mL [95%CI 0.6-5.1], P=0.017), respectively. Seven consecutive days of dosing significantly markedly elevated plasma volume (+491mL [95%CI 194-789], P=0.002). Phase II showed no significant effect on EPO, hemoglobin mass, plasma volume, V̇O2max, or 3 km time.CONCLUSIONS: Acute exposure to sub-anesthetic doses of xenon caused a consistent increase in EPO, and 7 consecutive days of xenon inhalation significantly expanded plasma volume. However, this physiological response appeared to be transient and 4 weeks of xenon inhalation did not stimulate increases in plasma volume or erythropoiesis, leaving cardiorespiratory fitness and athletic performance unchanged.

AB - BACKGROUND: This study aimed to assess the efficacy of acute sub-anesthetic dosages of xenon inhalation to cause erythropoiesis, and determine the effect of chronic xenon dosing on hematological parameters and athletic performance.METHODS: To assess the acute effects, 7 subjects breathed three sub-anesthetic concentrations of xenon: FiXe 30% for 20 minutes, FiXe 50% for 5 minutes and FiXe 70% for 2 minutes. EPO was measured at baseline, during and post xenon inhalation. To determine the chronic effects, 8 subjects breathed FiXe 70% for 2 minutes on 7 consecutive days, and EPO, total blood and plasma volume were measured. Phase II involved assessment of 12 subjects for EPO, total blood volume, V̇O2max, and 3km time before and after random assignment to 4 weeks of xenon or sham gas inhalation.RESULTS: FiXe 50% and 70% stimulated an increase in EPO at 6 hours (+2.3mIU/mL [95%CI 0.1-4.5], P=0.038) and at 192 hours post inhalation (+2.9mIU/mL [95%CI 0.6-5.1], P=0.017), respectively. Seven consecutive days of dosing significantly markedly elevated plasma volume (+491mL [95%CI 194-789], P=0.002). Phase II showed no significant effect on EPO, hemoglobin mass, plasma volume, V̇O2max, or 3 km time.CONCLUSIONS: Acute exposure to sub-anesthetic doses of xenon caused a consistent increase in EPO, and 7 consecutive days of xenon inhalation significantly expanded plasma volume. However, this physiological response appeared to be transient and 4 weeks of xenon inhalation did not stimulate increases in plasma volume or erythropoiesis, leaving cardiorespiratory fitness and athletic performance unchanged.

U2 - 10.1152/japplphysiol.00289.2019

DO - 10.1152/japplphysiol.00289.2019

M3 - Journal articles

C2 - 31414957

JO - Journal of applied physiology (Bethesda, Md. : 1985)

JF - Journal of applied physiology (Bethesda, Md. : 1985)

SN - 8750-7587

ER -

ID: 4878110