Effects of Cyclic Tensile Strain on Chondrocyte Metabolism: A Systematic Review

Research output: Contribution to journalJournal articlesResearchpeer-review

Authors

Research units

Details

Chondrocytes reorganize the extracellular matrix of articular cartilage in response to externally applied loads. Thereby, different loading characteristics lead to different biological responses. Despite of active research in this area, it is still unclear which parts of the extracellular matrix adapt in what ways, and how specific loading characteristics affect matrix changes. This review focuses on the influence of cyclic tensile strain on chondrocyte metabolism in vitro. It also aimed to identify anabolic or catabolic chondrocyte responses to different loading protocols. The key findings show that loading cells up to 3% strain, 0.17 Hz, and 2 h, resulted in weak or no biological responses. Loading between 3-10% strain, 0.17-0.5 Hz, and 2-12 h led to anabolic responses; and above 10% strain, 0.5 Hz, and 12 h catabolic events predominated. However, this review also discusses that various other factors are involved in the remodeling of the extracellular matrix in response to loading, and that parameters like an inflammatory environment might influence the biological response.

Original languageEnglish
JournalPloS one
Volume10
Issue number3
Pages (from-to)e0119816
Number of pages25
ISSN1932-6203
DOIs
Publication statusPublished - 2015

ID: 673845

View graph of relations