Effects of Cyclic Tensile Strain on Chondrocyte Metabolism: A Systematic Review

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Effects of Cyclic Tensile Strain on Chondrocyte Metabolism : A Systematic Review. / Bleuel, Judith; Zaucke, Frank; Brüggemann, Gert-Peter; Niehoff, Anja.

In: PloS one, Vol. 10, No. 3, 2015, p. e0119816.

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@article{69dcaed4f4b643d5a5dbd89d365f3311,
title = "Effects of Cyclic Tensile Strain on Chondrocyte Metabolism: A Systematic Review",
abstract = "Chondrocytes reorganize the extracellular matrix of articular cartilage in response to externally applied loads. Thereby, different loading characteristics lead to different biological responses. Despite of active research in this area, it is still unclear which parts of the extracellular matrix adapt in what ways, and how specific loading characteristics affect matrix changes. This review focuses on the influence of cyclic tensile strain on chondrocyte metabolism in vitro. It also aimed to identify anabolic or catabolic chondrocyte responses to different loading protocols. The key findings show that loading cells up to 3% strain, 0.17 Hz, and 2 h, resulted in weak or no biological responses. Loading between 3-10% strain, 0.17-0.5 Hz, and 2-12 h led to anabolic responses; and above 10% strain, 0.5 Hz, and 12 h catabolic events predominated. However, this review also discusses that various other factors are involved in the remodeling of the extracellular matrix in response to loading, and that parameters like an inflammatory environment might influence the biological response.",
author = "Judith Bleuel and Frank Zaucke and Gert-Peter Br{\"u}ggemann and Anja Niehoff",
year = "2015",
doi = "10.1371/journal.pone.0119816",
language = "English",
volume = "10",
pages = "e0119816",
journal = "PloS one",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "3",

}

RIS

TY - JOUR

T1 - Effects of Cyclic Tensile Strain on Chondrocyte Metabolism

T2 - A Systematic Review

AU - Bleuel, Judith

AU - Zaucke, Frank

AU - Brüggemann, Gert-Peter

AU - Niehoff, Anja

PY - 2015

Y1 - 2015

N2 - Chondrocytes reorganize the extracellular matrix of articular cartilage in response to externally applied loads. Thereby, different loading characteristics lead to different biological responses. Despite of active research in this area, it is still unclear which parts of the extracellular matrix adapt in what ways, and how specific loading characteristics affect matrix changes. This review focuses on the influence of cyclic tensile strain on chondrocyte metabolism in vitro. It also aimed to identify anabolic or catabolic chondrocyte responses to different loading protocols. The key findings show that loading cells up to 3% strain, 0.17 Hz, and 2 h, resulted in weak or no biological responses. Loading between 3-10% strain, 0.17-0.5 Hz, and 2-12 h led to anabolic responses; and above 10% strain, 0.5 Hz, and 12 h catabolic events predominated. However, this review also discusses that various other factors are involved in the remodeling of the extracellular matrix in response to loading, and that parameters like an inflammatory environment might influence the biological response.

AB - Chondrocytes reorganize the extracellular matrix of articular cartilage in response to externally applied loads. Thereby, different loading characteristics lead to different biological responses. Despite of active research in this area, it is still unclear which parts of the extracellular matrix adapt in what ways, and how specific loading characteristics affect matrix changes. This review focuses on the influence of cyclic tensile strain on chondrocyte metabolism in vitro. It also aimed to identify anabolic or catabolic chondrocyte responses to different loading protocols. The key findings show that loading cells up to 3% strain, 0.17 Hz, and 2 h, resulted in weak or no biological responses. Loading between 3-10% strain, 0.17-0.5 Hz, and 2-12 h led to anabolic responses; and above 10% strain, 0.5 Hz, and 12 h catabolic events predominated. However, this review also discusses that various other factors are involved in the remodeling of the extracellular matrix in response to loading, and that parameters like an inflammatory environment might influence the biological response.

U2 - 10.1371/journal.pone.0119816

DO - 10.1371/journal.pone.0119816

M3 - Journal articles

C2 - 25822615

VL - 10

SP - e0119816

JO - PloS one

JF - PloS one

SN - 1932-6203

IS - 3

ER -

ID: 673845